MEDICINAL CHEMISTRY C

CHE3MCC

2015

Credit points: 30

Subject outline

CHE3MCC is a core 3rd year subject required for a Medicinal Chemistry major, along with CHE3MCD. Learning activities within the subject include lectures, tutorials, workshops and laboratory classes. Core topics address the areas of bioinorganic and medicinal chemistry, organic synthesis and techniques for chemical analysis (e.g. nuclear magnetic resonance, mass spectrometry, separation science, atomic spectroscopy). One optional topic must also be selected, from areas such as bonding, sustainability and chemistry, polymer chemistry.

SchoolSchool of Molecular Sciences/LIMS

Credit points30

Subject Co-ordinatorBelinda Abbott

Available to Study Abroad StudentsYes

Subject year levelYear Level 3 - UG

Exchange StudentsYes

Subject particulars

Subject rules

Prerequisites Admission into SBMC and either (CHE2FCA and CHE2FCB and CHE2MOC) or CHE2MEC.

Co-requisitesN/A

Incompatible subjects CHE3ADA

Equivalent subjectsN/A

Special conditions Optional topics may vary from year to year.

Readings

Resource TypeTitleResource RequirementAuthor and YearPublisher
ReadingsAn Introduction to Medicinal ChemistryPrescribedPatrick, G.4TH EDN, OXFORD UNIVERSITY PRESS, 2009.
ReadingsOrganic Chemistry, 8th ed.PrescribedMcMurry, J.THOMSON]BROOKS/COLE, 2011.
ReadingsQuantitative Chemical Analysis, 8th edPrescribedHarris, D.C.FREEMAN, 2010.
ReadingsSpectrometric Identification of Organic CompoundsPrescribedSilverstein, Webster & KiemleWILEY, 7TH ED, 2005.

Graduate capabilities & intended learning outcomes

01. Demonstrate thorough understanding of "Key Principles of Chemistry" as defined by the Royal Australian Chemical Institute and employ experimental methods of investigation of the defined principles.

Activities:
During lectures students will answer short questions individually or as part of small groups, reinforcing lecture material. In tutorials and in their own time students will apply these concepts to solve a variety of problems, some of which are assessed via quizzes or assignments and others which are provided as optional problem sets for exam preparation.
Related graduate capabilities and elements:

02. Apply professional integrity and safe laboratory practices when designing and performing experiments, colecting data and reporting results, in order to satisfy the professional accreditation requirements of the Royal Australian Chemical Institute.

Activities:
Students are explicitly briefed on safe laboratory practices and given an assignment on risk assessment and use of material safety data sheets. Working individually or in small groups, students will aquire practical skills required for the manipulation of chemicals for chemical synthesis and learn how to use modern instrumentation to perform chemical analyses. Student laboratory reports and assignments are compared to ensure authenticity and mark allocation or penalty applied.
Related graduate capabilities and elements:

03. Apply relevant mathematical, graphical and computational methods to acquire, manipulate, interpret and evaluate chemical data and summarise results using appropriate significant figures and units.

Activities:
Student calculations are submitted in subject assignments, laboratory reports and exams and are assessed for accuracy of result and logical structure. The evaluation and reporting of errors and uncertainties is particularly dealt with in the laboratory assessment.
Related graduate capabilities and elements:

04. Write coherent descriptions of chemical principles and report experimental results with well supported interpretations using correctly referenced professional prose.

Activities:
Laboratory reports: students submit laboratory reports throughout the semester that are marked against a rubric for professional presentation. Reports returned in a timely manner and annotated with helpful comments to aid improvement. Topic assignments: students submit topic assignments throughout the semester that are marked against a rubric for professional prose and accurate description of information including references where appropriate. Assignments returned and annotated with helpful comments to aid improvement.
Related graduate capabilities and elements:
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)

05. Solve abstract, routine and real-world problems of chemical relevance by sourcing, collating and summarising legitimate scientific information.

Activities:
In tutorial problem classes and assignments students must apply chemical concepts to solve a variety of problems and draw from appropriate chemical data sources to do so. In the laboratory context, a referencing and databases assignment trains students in using the chemical literature.
Related graduate capabilities and elements:

06. Orally present chemistry matters, supported by legitimate evidence and appropriately defended to peers or professionals.

Activities:
Students will be expected to orally explain their answers and participate in tutorial discussions on a regular basis. Students present a 10-minute seminar on a completed laboratory experiment that is peer and demonstrator assessed against a rubric for professional prose, presentation of information and data, critical evaluation and summary of results.
Related graduate capabilities and elements:
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)

Subject options

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Start date between: and    Key dates

Melbourne, 2015, Semester 1, Day

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Enrolment information

Subject Instance Co-ordinatorBelinda Abbott

Class requirements

Tutorial Week: 10 - 22
Two 1.0 hours tutorial per week on weekdays during the day from week 10 to week 22 and delivered via face-to-face.

Lecture Week: 10 - 22
Four 1.0 hours lecture per week on weekdays during the day from week 10 to week 22 and delivered via face-to-face.

Laboratory Class Week: 10 - 22
One 6.0 hours laboratory class per week on weekdays during the day from week 10 to week 22 and delivered via face-to-face.

Assessments

Assessment elementComments% ILO*
Assignments (2500 words total). These are formative assessment tasks completed during semester.A hurdle requirement of 50% applies to laboratory assessment, and also to the overall exam component comprised of core and optional topic exams.25 01, 03, 04, 05
Laboratory exercises and written reports. The results from one experiment are presented orally.30 01, 02, 03, 04, 05, 06
Two exams (total 4.5 hrs). Subject matter from 38 lectures with written answers & problem solving.45 01, 03, 04, 05