pha2pgb pharmacology b
PHARMACOLOGY B
PHA2PGB
2019
Credit points: 15
Subject outline
This subject will introduce how variation in human molecular genetics may affect pharmacokinetics and pharmacodynamics of drugs. Examples will focus on mutations associated with metabolizing and excreting drugs and potential for toxicity. Immune responses from a cellular and molecular perspective will be introduced incorporating innate immunity, inflammation, chemical cascades, adaptive immunity and cells of the immune system. The capacity for clonal variations in acquired immunity based pharmacogenetics will be explored.
SchoolSchool of Molecular Sciences/LIMS
Credit points15
Subject Co-ordinatorCristina Keightley
Available to Study Abroad StudentsYes
Subject year levelYear Level 2 - UG
Exchange StudentsYes
Subject particulars
Subject rules
Prerequisites BIO1CO or BIO1OF or BIO1MGC or BIO1OOS
Co-requisitesN/A
Incompatible subjectsN/A
Equivalent subjectsN/A
Special conditionsN/A
Learning resources
Readings
| Resource Type | Title | Resource Requirement | Author and Year | Publisher |
|---|---|---|---|---|
| Readings | Human Genetics | Recommended | Lewis, R 2008 | 9TH ED MCGRAW-HILL. NEW YORK. |
| Readings | Basic Immunology: Functions and disorders of the immune system | Recommended | Abbas, A B, Lichtman, A H and Pillai S 2016 | 5th ed Elsevier |
Graduate capabilities & intended learning outcomes
01. Use an understanding of the variability within and between populations to interpret effects on drug metabolism.
- Activities:
- The impact of variability within and between populations will be examined in lectures and reinforced in tutorials. Understanding will be assessed in the mid- semester test and final examination.
- Related graduate capabilities and elements:
- Literacies and Communication Skills(Writing,Speaking,Quantitative Literacy)
- Literacies and Communication Skills(Writing,Speaking,Quantitative Literacy)
- Inquiry and Analytical Skills(Critical Thinking,Creative Problem-solving,Inquiry/Research)
- Discipline -Specific Knowledge and Skills(Discipline-Specific Knowledge and Skills)
02. Evaluate how the variability in pharmocogenetics can cause toxic levels of drugs to circulate.
- Activities:
- The influence of variability in pharmacogenetics on toxicity levels be explained in lectures and reinforced in tutorials. Understanding will be assessed in the final examination.
- Related graduate capabilities and elements:
- Literacies and Communication Skills(Writing,Speaking,Quantitative Literacy)
- Literacies and Communication Skills(Writing,Speaking,Quantitative Literacy)
- Inquiry and Analytical Skills(Critical Thinking,Creative Problem-solving,Inquiry/Research)
- Inquiry and Analytical Skills(Critical Thinking,Creative Problem-solving,Inquiry/Research)
- Discipline -Specific Knowledge and Skills(Discipline-Specific Knowledge and Skills)
03. Assess different causes of pharmaceutical toxicity, including physiological change during human development, as a result of drug overdose or in a range of diseases.
- Activities:
- Causes of toxicity will be explained in lectures and reinforced in tutorials. Understanding will be assessed in the mid-semester test and final examination.
- Related graduate capabilities and elements:
- Literacies and Communication Skills(Writing,Speaking,Quantitative Literacy)
- Literacies and Communication Skills(Writing,Speaking,Quantitative Literacy)
- Inquiry and Analytical Skills(Critical Thinking,Creative Problem-solving,Inquiry/Research)
- Discipline -Specific Knowledge and Skills(Discipline-Specific Knowledge and Skills)
04. Explain the process of inflammation and the steps involved in initiation of the immune response to analyse drug interactions with the immune system.
- Activities:
- The inflamation and the immune recognition system will be presented in lectures. Understanding will be assessed in the final examnation.
- Related graduate capabilities and elements:
- Literacies and Communication Skills(Writing,Speaking,Quantitative Literacy)
- Literacies and Communication Skills(Writing,Speaking,Quantitative Literacy)
- Inquiry and Analytical Skills(Critical Thinking,Creative Problem-solving,Inquiry/Research)
- Inquiry and Analytical Skills(Critical Thinking,Creative Problem-solving,Inquiry/Research)
- Personal and Professional Skills(Teamwork including leadership and working in groups,Ethical behaviour)
- Discipline -Specific Knowledge and Skills(Discipline-Specific Knowledge and Skills)
05. Discuss how immunogenetics gives rise to clonal variation to fight infection.
- Activities:
- Immunogenetics will be presented during class time. Understanding will be assessed in the final examination.
- Related graduate capabilities and elements:
- Literacies and Communication Skills(Writing,Speaking,Quantitative Literacy)
- Literacies and Communication Skills(Writing,Speaking,Quantitative Literacy)
- Discipline -Specific Knowledge and Skills(Discipline-Specific Knowledge and Skills)
Subject options
Select to view your study options…
Albury-Wodonga, 2019, Semester 2, Day
Overview
Online enrolmentYes
Maximum enrolment sizeN/A
Enrolment information
Subject Instance Co-ordinatorCathryn Hogarth
Class requirements
LectureWeek: 31 - 43
Two 1.0 hours lecture per week on weekdays during the day from week 31 to week 43 and delivered via face-to-face.
"24-hours of Blended Lectures and Online Learning Activities in the teaching period delivered as a combination of face-to-face and online."
TutorialWeek: 31 - 43
One 2.0 hours tutorial per week on weekdays during the day from week 31 to week 43 and delivered via face-to-face.
"24-hours of Tutorial or Directed Learning Activities during the teaching period and delivered via face-to-face or online."
Assessments
| Assessment element | Comments | % | ILO* |
|---|---|---|---|
| 2-hour end of semester written examination | 50 | 01, 02, 03, 04, 05 | |
| 1-hour mid-semester test | 15 | 01, 02, 03, 04 | |
| One group review article (750-words per student) | 25 | 01, 02, 03, 04 | |
| 3 x online tests during semester (500-words equivalent) | 10 | 01, 02, 03, 04, 05 |
Bendigo, 2019, Semester 2, Day
Overview
Online enrolmentYes
Maximum enrolment sizeN/A
Enrolment information
Subject Instance Co-ordinatorCristina Keightley
Class requirements
LectureWeek: 31 - 43
Two 1.0 hours lecture per week on weekdays during the day from week 31 to week 43 and delivered via face-to-face.
"24-hours of Blended Lectures and Online Learning Activities in the teaching period delivered as a combination of face-to-face and online."
TutorialWeek: 31 - 43
One 2.0 hours tutorial per week on weekdays during the day from week 31 to week 43 and delivered via face-to-face.
"24-hours of Tutorial or Directed Learning Activities during the teaching period and delivered via face-to-face or online.
"
Assessments
| Assessment element | Comments | % | ILO* |
|---|---|---|---|
| 2-hour end of semester written examination | 50 | 01, 02, 03, 04, 05 | |
| 1-hour mid-semester test | 15 | 01, 02, 03, 04 | |
| One group review article (750-words per student) | 25 | 01, 02, 03, 04 | |
| 3 x online tests during semester (500-words equivalent) | 10 | 01, 02, 03, 04, 05 |
Singapore (PSB), 2019, Term L3, Night
Overview
Online enrolmentYes
Maximum enrolment sizeN/A
Enrolment information
Subject Instance Co-ordinatorJennifer Selkirk-Bell
Class requirements
TutorialWeek: 19 - 23
One 12.0 hours tutorial per study period on weekdays at night from week 19 to week 23 and delivered via face-to-face.
"12-hours of Tutorial or Directed Learning Activities during the teaching period and delivered via face-to-face or online."
LectureWeek: 19 - 23
One 36.0 hours lecture per study period on weekdays at night from week 19 to week 23 and delivered via face-to-face.
"36-hours of Blended Lectures and Online Learning Activities in the teaching period delivered as a combination of face-to-face and online."
Assessments
| Assessment element | Comments | % | ILO* |
|---|---|---|---|
| 2-hour end of semester written examination | 50 | 01, 02, 03, 04, 05 | |
| 1-hour mid-semester test | 15 | 01, 02, 03, 04 | |
| One group review article (750-words per student) | 25 | 01, 02, 03, 04 | |
| 3 x online tests during semester (500-words equivalent) | 10 | 01, 02, 03, 04, 05 |
Singapore (PSB), 2019, Term L3, Day
Overview
Online enrolmentYes
Maximum enrolment sizeN/A
Enrolment information
Subject Instance Co-ordinatorJennifer Selkirk-Bell
Class requirements
LectureWeek: 19 - 23
One 36.0 hours lecture per study period on weekdays during the day from week 19 to week 23 and delivered via face-to-face.
"36-hours of Blended Lectures and Online Learning Activities in the teaching period delivered as a combination of face-to-face and online."
TutorialWeek: 19 - 23
One 12.0 hours tutorial per study period on weekdays during the day from week 19 to week 23 and delivered via face-to-face.
"12-hours of Tutorial or Directed Learning Activities during the teaching period and delivered via face-to-face or online."
Assessments
| Assessment element | Comments | % | ILO* |
|---|---|---|---|
| 2-hour end of semester written examination | 50 | 01, 02, 03, 04, 05 | |
| 1-hour mid-semester test | 15 | 01, 02, 03, 04 | |
| One group review article (750-words per student) | 25 | 01, 02, 03, 04 | |
| 3 x online tests during semester (500-words equivalent) | 10 | 01, 02, 03, 04, 05 |
Singapore (PSB), 2019, Term L1, Day
Overview
Online enrolmentYes
Maximum enrolment sizeN/A
Enrolment information
Subject Instance Co-ordinatorJennifer Selkirk-Bell
Class requirements
LectureWeek: 02 - 07
One 36.0 hours lecture per study period on weekdays during the day from week 02 to week 07 and delivered via face-to-face.
"36-hours of Blended Lectures and Online Learning Activities in the teaching period delivered as a combination of face-to-face and online."
TutorialWeek: 02 - 07
One 12.0 hours tutorial per study period on weekdays during the day from week 02 to week 07 and delivered via face-to-face.
"12-hours of Tutorial or Directed Learning Activities during the teaching period and delivered via face-to-face or online."
Assessments
| Assessment element | Comments | % | ILO* |
|---|---|---|---|
| 2-hour end of semester written examination | 50 | 01, 02, 03, 04, 05 | |
| 1-hour mid-semester test | 15 | 01, 02, 03, 04 | |
| One group review article (750-words per student) | 25 | 01, 02, 03, 04 | |
| 3 x online tests during semester (500-words equivalent) | 10 | 01, 02, 03, 04, 05 |