MEDICINAL CHEMISTRY A

CHE2MCA

2015

Credit points: 15

Subject outline

Students will be introduced to new chemical principles that are required to understand the action and behaviour of drug compounds. The main areas of study include an introduction to the chemistry and nomenclature of carbohydrates, lipids, steroids and heterocyclic compounds. This unit will provide an understanding of how the chemical structure and behaviour of drug molecules relate to the activity of drugs in biological systems, and how this knowledge can be used to devise strategies for drug design and principles of drug structure-activity relationships (SAR and QSAR), drug-receptor interactions. This unit will also contain a computer based practical component.

SchoolSchool of Molecular Sciences/LIMS

Credit points15

Subject Co-ordinatorJasim Al-Rawi

Available to Study Abroad StudentsYes

Subject year levelYear Level 2 - UG

Exchange StudentsYes

Subject particulars

Subject rules

Prerequisites CHE1C1B

Co-requisitesN/A

Incompatible subjectsN/A

Equivalent subjectsN/A

Special conditionsN/A

Readings

Resource TypeTitleResource RequirementAuthor and YearPublisher
ReadingsAn Introduction to Medicinal ChemistryPrescribedPatrick G 20043RD ED. OXFORD, NEW YORK
ReadingsAn Introduction to Medicinal ChemistryPrescribedThomas G. 2001WILEY, WEST SUSSEX
ReadingsLecture semi-notes and practical are lodged on the LMSPrescribedN/AN/A
ReadingsOrganic chemistryPrescribedBruice, PY 20075TH ED, PRENTICE-HALL, INC, NEW JERSEY.

Graduate capabilities & intended learning outcomes

01. Demonstrate the use of the major concepts and language of pharmaceutical and medicinal chemistry by completing supplied practice problems and writing answers on tests and exam, and in written practical reports.

Activities:
Taught in lectures, tutorials, practical workshops, practice problems from text. Assessed in tests and exam.
Related graduate capabilities and elements:
Quantitative Literacy/ Numeracy (Quantitative Literacy/ Numeracy)
Writing (Writing)
Discipline-specific GCs (Discipline-specific GCs)

02. Demonstrate an advanced understanding of the chemistry of organic compounds by describing functional group chemistry and how this impacts on activity with cell-receptors (SAR), identifying pharmacophores, and by describing and illustrating major synthesis steps used to modify organic molecules to enhance drug efficacy.

Activities:
Taught in lectures, tutorials, practical workshops, practice problems from text and online. Assessed in tests, exam and practical workshop reports.
Related graduate capabilities and elements:
Critical Thinking (Critical Thinking)
Discipline-specific GCs (Discipline-specific GCs)
Creative Problem-solving (Creative Problem-solving)

03. Given a drug structure identify and predict likely metabolic and elimination pathways, describe likely routes of administration by considering issues such as solubility and metabolism.

Activities:
Taught in lectures, tutorials, practical workshops, practice problems from text and online. Assessed in tests, exam and practical workshop reports.
Related graduate capabilities and elements:
Critical Thinking (Critical Thinking)
Discipline-specific GCs (Discipline-specific GCs)
Creative Problem-solving (Creative Problem-solving)

Subject options

Select to view your study options…

Start date between: and    Key dates

Bendigo, 2015, Semester 1, Day

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Enrolment information

Subject Instance Co-ordinatorJasim Al-Rawi

Class requirements

Computer Laboratory Week: 10 - 22
Two 3.0 hours computer laboratory per study period on weekdays during the day from week 10 to week 22 and delivered via face-to-face.
"Computer Laboratory simulation Delivery Method: Or On-Line"

Lecture Week: 10 - 22
Three 1.0 hours lecture per week on weekdays during the day from week 10 to week 22 and delivered via face-to-face.
"Or Delivery Method: On-Line"

Tutorial Week: 10 - 22
One 1.0 hours tutorial per week on weekdays during the day from week 10 to week 22 and delivered via face-to-face.
"Type: Or On-Line Quiz Delivery Method: Or On-Line"

Assessments

Assessment elementComments% ILO*
One 3hr written examination70 01, 02, 03
Two class tests (10% each)20 01, 02, 03
Two laboratory reports10 02, 03

Singapore, 2015, Semester 1, Blended

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Enrolment information

Subject Instance Co-ordinatorJasim Al-Rawi

Class requirements

Tutorial Week: 10 - 22
One 12.0 hours tutorial per study period on weekdays during the day from week 10 to week 22 and delivered via face-to-face.
"12-hours of tutorials or online quizzes during the teaching period and delivered via face-to-face or online."

Lecture Week: 10 - 22
One 36.0 hours lecture per study period on weekdays during the day from week 10 to week 22 and delivered via face-to-face.
"36-hours of Blended Lectures and Online Learning Activities in the teaching period delivered as a combination of face-to-face and online."

Computer Laboratory Week: 10 - 22
One 6.0 hours computer laboratory per study period on weekdays during the day from week 10 to week 22 and delivered via face-to-face.
"6-hours of computer laboratory during the teaching period and delivered via face-to-face or online."

Assessments

Assessment elementComments% ILO*
One 3hr written examination70 01, 02, 03
Two class tests (10% each)20 01, 02, 03
Two laboratory reports10 02, 03