Whelan - Biophysics, DNA damage, fluorescence, single molecule imaging
Dr Donna Whelan
Research Fellow, College of Science, Health and Engineering
We specialize in applying state-of-the-art techniques to biological questions. In particular we make use of microscopic and spectroscopic methods to visualize the compositions and ultrastructures of individual cells and their subcomponents. These experiments offer a unique approach to probing crucial cellular pathways, the disease mechanisms that perturb them, and potential future treatments. Specifically, single molecule fluorescence techniques including super resolution imaging and Forster resonance energy transfer are used in tandem with infrared spectroscopic approaches to probe DNA damage response, DNA double strand break repair, viral perturbation of host cell structures, and the role of DNA damage in neurodegenerative disorders.
- Visualizing DNA damage and repair using single molecule super resolution imaging
- Developing a correlative and complementary pipeline of advanced biophysical techniques
- Investigating the dynamics of DNA strand invasion using single molecule Forster Resonance Energy Transfer (FRET)
- New assays for imaging cell structures using live cell super-resolution and expansion microscopies