Our group examines the molecular mechanisms underlying cell fate decisions dictated by the processes of apoptosis and autophagy.
Our group develops new therapeutic strategies for cancer treatment. We examine the mechanism of action of available anticancer drugs and work to restrict the killing properties to cancerous cell types.
Our group use a combination of biochemistry, cell biology, structural biology and medicinal chemistry approaches to understand the precise molecular mechanisms that control apoptosis.
Our group uses an integrated system biology approach to understand extracellular communication in the context of the tumour microenvironment and uterine development.
Our group examines apoptotic regulation in normal cells, cancerous cells and virally-infected cells. We use this knowledge to explore better and safer therapies for cancer and viral diseases.
Our group specialises in cancer cachexia, a complication of cancer that is responsible for around 25% of cancer deaths.
Our laboratory is interested in how cell asymmetry and tissue organisation can regulate cancer initiation, progression and metastasis.
Our group characterises the macromolecular complexes in the nucleus to understand their roles in gene regulation and DNA damage repair pathway.
Our group explores the role of extracellular matrix components (soluble secreted proteins and extracellular vesicles) in cancer and intercellular communication.
Our group uses the vinegar fly, Drosophila, to model cancer with the vision of understanding how regulators of cell shape (polarity) and the cell skeleton (actin cytoskeleton) impact on cell signalling and cancer development.
Our group utilizes an integrated proteomic/genomic strategy to understand the role of the extracellular environment in cancer progression.
Our group studies the function of mitochondrial proteins involved in the biogenesis and maintenance of mitochondria at the molecular level.
Our group develops and applies advanced fluorescence imaging techniques to visualize cells at the single molecule and nano-scale. In particular, we are working to understand DNA damage and repair.