The Cancer theme investigates the mechanisms of cancer initiation and progression, the crosstalk between cancer cells and the surrounding environment, and the potential of novel therapeutic approaches for combating disease.
Research spans the fields of cancer metastasis, cancer cell crosstalk with the microenvironment, tumour architecture, pro- and anti-tumour immunity, and therapeutic sensitivity and resistance.
Members have expertise in confocal microscopy, in vivo bioluminescent and fluorescent imaging, fluorescence-activated cell sorting, 3D cell cultures, Drosophila genetics, proteomic profiling, gene knockout/overexpression, DNA damage assessment, monitoring immune cell infiltration, activation and impact, stem cells, cancer cell invasion, EMT, metastasis assays and DNA/RNA sequencing.
Current projects work to identify key drivers of cancer progression including secreted or exosomal factors, and loss of cell polarity; the targets, mechanisms of resistance and side effects of therapeutics; development of novel biomarkers for predicting cancer spread; and identification of ways that cancer cells co-opt the immune system to promote progression.
We collaborate closely with the Olivia Newton-John Cancer Research Institute.