Richardson - Cell polarity, cell signalling and cancer
Dr Helena Richardson
Associate Professor, College of Science, Health and Engineering
Our group uses the vinegar fly, Drosophila, to model cancer with the vision of understanding how regulators of cell shape (polarity) impact on cell signaling and cancer development. Additionally, we seek to understanding the signaling pathways in the tumour microenvironment that dictate whether polarity-impaired mutant cells live or die. To achieve this, we collaborate with Professor Patrick Humbert (Cancer Theme), Dr Marc Kvansakul (Molecular Imaging Theme) and Professor Andrew Hill (Neurobiology Theme).
- Understanding how cell polarity regulators control endocytosis, vesicle acidification and cell signalling
- Understanding how perturbations in cell polarity affect cell competition in tissue development
- Modelling cooperative tumourigenesis in Drosophila: understanding the link between cell polarity, cell signalling, tissue growth and tumourigenesis
- Discovery of novel anti-cancer drugs using Drosophila tumour models