Publications

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Chen A, Sceneay J, Gödde N, Kinwel T, Ham S, Thompson EW, Humbert PO* and Möller A* (2018) Intermittent hypoxia induces a metastatic phenotype in breast cancer, Oncogene, doi: 10.1038/s41388-018-0259-3. (* Co-Senior Authors)

Kvansakul M and Humbert PO (2018) Cell Polarity Regulation - from Atomic to Macroscopic Scale, Journal of Molecular Biology, doi: 10.1016/j.jmb.2018.07.021.

Pearson HB, Li J, Meniel VS, Fennell CM, Waring P, Montgomery KG, Rebello RJ, Macpherson AA, Koushyar S, Furic L, Cullinane C, Clarkson RW, Smalley MJ, Simpson KJ, Phesse TJ, Shepherd PR, Humbert PO, Sansom OJ and Phillips WA (2018) Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth, Cancer Discov, doi: 10.1158/2159-8290.CD-17-0867.

Stephens R, Lim K, Portela M, Kvansakul M, Humbert PO and Richardson HE (2018) The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis, J Mol Biol, doi: 10.1016/j.jmb.2018.01.011.

Caria S, Magtoto CM, Samiei T, Portela M, Lim KYB, How JY, Stewart BZ, Humbert PO*, Richardson HE* and Kvansakul M* (2018) Drosophila melanogaster Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large, J Biol Chem, 293(12): 4519-4531. (* Co-Senior Authors)

Lim KYB, Gödde NJ, Humbert PO* and Kvansakul M* (2017) Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor β-PIX, J Biol Chem., 292(50): 20425-20436. (* Co-Senior Authors)

Milgrom-Hoffman M and Humbert PO (2017) Regulation of cellular and PCP signalling by the Scribble polarity module, Semin Cell Dev Biol., pii: S1084-9521(16)30335-4, doi: 10.1016/j.semcdb.2017.11.021.

Manent J, Banerjee S, de Matos Simoes R, Zoranovic T, Mitsiades C, Penninger JM, Simpson KJ, Humbert PO and Richardson HE (2017) Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species, Oncogene, 36(40): 5576-5592.

Wölwer CB and Humbert PO (2017) How to expel a bad tenant: Linking cyclin A2, enucleation and cell size, Cell Cycle, 16(5): 397-98.

Wölwer CB, Gödde N, Pase LB, Elsum IA, Lim KY, Sacirbegovic F, Walkley CR, Ellis S, Ohno S, Matsuzaki F, Russell SM and Humbert PO (2017) The asymmetric cell division regulators Par3, Scribble and Pins/Gpsm2 are not essential for erythroid development or enucleation, PLoS One, 12(1): e0170295.

Smith LK, Thomas DW, Simpson KJ and Humbert PO (2016) A phenotypic high-content screening assay to identify regulators of membrane protein localisation, Assay Drug Dev Technol., 14(8): 478-88.

Lindley RA, Humbert P, Larner C, Akmeemana EH and Pendlebury CR (2016) Association between targeted somatic mutation (TSM) signatures and HGS-OvCa progression, Cancer Med, 5(9): 2629-40.

Wölwer CB, Pase LB, Russell SM and Humbert PO (2016) Calcium signaling is required for erythroid enucleation, PLoS One, 11(1): e0146201.

Hawkins ED, Oliaro J, Ramsbottom KM, Newbold A, Humbert PO, Johnstone RW and Russell SM (2016) Scribble acts as an oncogene in Eμ-myc-driven lymphoma, Oncogene, 35(9): 1193-7.

Ramsbottom KM, Sacirbegovic F, Hawkins ED, Kallies A, Belz GT, Van Ham V, Haynes NM, Durrant MJ, Humbert PO, Russell SM and Oliaro J (2016) Lethal giant larvae-1 deficiency enhances the CD8(+) effector T-cell response to antigen challenge in vivo, Immunol Cell Biol., 94(3): 306-11.

Pearson HB, McGlinn E, Phesse TJ, Schlüter H, Srikumar A, Gödde NJ, Woelwer CB, Ryan A, Phillips WA, Ernst M, Kaur P and Humbert P (2015) The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis, Mol Cancer, 14: 169, doi: 10.1186/s12943-015-0440-z.

Wölwer CB, Pase LB, Pearson HB, Gödde NJ, Lackovic K, Huang DC, Russell SM and Humbert PO (2015) A chemical screening approach to identify novel key mediators of erythroid enucleation, PLoS One, 10(11): e0142655.

Pham K, Shimoni R, Charnley M, Ludford-Menting MJ, Hawkins ED, Ramsbottom K, Oliaro J, Izon D, Ting SB, Reynolds J, Lythe G, Molina-Paris C, Melichar H, Robey E, Humbert PO, Gu M and Russell SM (2015) Asymmetric cell division during T cell development controls downstream fate, J Cell Biol., 210(6): 933-50.

Kruse C, Kurz AR, Pálfi K, Humbert PO, Sperandio M, Brandes RP, Fork C and Michaelis UR (2015) Polarity protein Scrib facilitates endothelial inflammatory signaling, Arterioscler Thromb Vasc Biol., 35(9): 1954-62.

Humbert PO and Gödde NJ (2015) Mitotic spindle orientation: semaphorin-plexin signaling flags the way, Dev Cell, 33(3): 243-44.

Jarjour AA, Boyd A, Dow LE, Holloway RK, Goebbels S, Humbert PO, Williams A and Ffrench-Constant C.(2015) The polarity protein Scribble regulates myelination and remyelination in the central nervous system, PLoS Biol, 13(3): e1002107, doi: 10.1371/journal.pbio.1002107.

Ono Y, Urata Y, Goto S, Nakagawa S, Humbert PO, Li TS and Zammit PS (2015) Muscle stem cell fate is controlled by the cell-polarity protein Scrib, Cell Rep, 10(7): 1135-48.

Takizawa I, Lawrence MG, Balanathan P, Rebello R, Pearson HB, Garg E, Pedersen J, Pouliot N, Nadon R, Watt MJ, Taylor RA, Humbert P, Topisirovic I, Larsson O, Risbridger GP and Furic L (2015) Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity, Oncotarget, 6(2): 604-16.

Godde NJ, Sheridan JM, Smith LK, Pearson HB, Britt KL, Galea RC, Yates LL, Visvader JE and Humbert PO (2014) Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland, PLoS Genet., 10(5): e1004323.

Elsum IA, Yates LL, Pearson HB, Phesse TJ, Long F, O'Donoghue R, Ernst M, Cullinane C and Humbert PO (2014) Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo, Oncogene, 33(48): 5523-33.

Gödde NJ, Pearson HB, Smith LK and Humbert PO (2014) Dissecting the role of polarity regulators in cancer through the use of mouse models, Exp Cell Res., 328(2): 249-57.

DiTommaso T, Cottle DL, Pearson HB, Schlüter H, Kaur P, Humbert PO and Smyth IM (2014) Keratin 76 is required for tight junction function and maintenance of the skin barrier, PLoS Genet., 10(10): e1004706.

Boczonadi V, Gillespie R, Keenan I, Ramsbottom SA, Donald-Wilson C, Al Nazer M, Humbert P, Schwarz RJ, Chaudhry B and Henderson DJ (2014) Scrib:Rac1 interactions are required for the morphogenesis of the ventricular myocardium, Cardiovasc Res., 104(1): 103-15.

Hawkins ED, Oliaro J, Ramsbottom KM, Ting SB, Sacirbegovic F, Harvey M, Kinwell T, Ghysdael J, Johnstone RW, Humbert PO and Russell SM (2014) Lethal giant larvae 1 tumour suppressor activity is not conserved in models of mammalian T and B cell leukaemia, PLoS One, 9(1): e87376.

Elsum IA, Martin C and Humbert PO (2013) Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation, J Cell Sci., 126(Pt 17): 3990-99.

Elsum IA and Humbert PO (2013) Localization, not important in all tumor-suppressing properties: a lesson learnt from scribble, Cells Tissues Organs, 198(1): 1-11.

Cater MA, Pearson HB, Wolyniec K, Klaver P, Bilandzic M, Paterson BM, Bush AI, Humbert PO, La Fontaine S, Donnelly PS and Haupt Y (2013) Increasing intracellular bioavailable copper selectively targets prostate cancer cells, ACS Chem Biol., 8(7): 1621-31.

Hawkins ED, Oliaro J, Kallies A, Belz GT, Filby A, Hogan T, Haynes N, Ramsbottom KM, Van Ham V, Kinwell T, Seddon B, Davies D, Tarlinton D, Lew AM, Humbert PO and Russell SM (2013) Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity, Nat Commun., 4: 1801, doi: 10.1038/ncomms2796.

Namdarian B, Wong E, Galea R, Pedersen J, Chin X, Speirs R, Humbert PO, Costello AJ, Corcoran NM and Hovens CM (2013) Loss of APKC expression independently predicts tumor recurrence in superficial bladder cancers, Urol Oncol., 31(5): 649-55.

Gaire RK, Smith L, Humbert P, Bailey J, Stuckey PJ and Haviv I (2013) Discovery and analysis of consistent active sub-networks in cancers, BMC Bioinformatics, 14 Suppl 2: S7, doi: 10.1186/1471-2105-14-S2-S7.

Humphries LA, Shaffer MH, Sacirbegovic F, Tomassian T, McMahon KA, Humbert PO, Silva O, Round JL, Takamiya K, Huganir RL, Burkhardt JK, Russell SM and Miceli MC (2012) Characterization of in vivo Dlg1 deletion on T cell development and function, PLoS One, 7(9): e45276.

Willoughby LF, Schlosser T, Manning SA, Parisot JP, Street IP, Richardson HE, Humbert PO and Brumby AM (2012) An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery, Dis Model Mech., 6(2): 521-29.

Elsum I, Yates L, Humbert PO and Richardson HE (2012) The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man, Essays Biochem., 53: 141-68.

Tikoo A, Roh V, Montgomery KG, Ivetac I, Waring P, Pelzer R, Hare L, Shackleton M, Humbert P and Phillips WA (2012) Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors, PLoS One, 7(5): e36924.