Compositions and methods for reducing bacterial aggregation: New Australian Provisional Patent Application 2018903096


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Walden PW, Premkumar L, Halili M, Heras B, King G, Whitten AE and  Martin JL (2019) The atypical thiol-disulfide exchange protein alpha-DsbA2 from Wolbachia pipientis is a homotrimeric disulfide isomerase, Acta Cryst. D, (Accepted 29/12/2018).

Smith RP, Mohanty B, Mowlaboccus S, Paxman JJ, Williams ML, Headey SJ, Wang G, Subedi P, Doak BC, Kahler CM, Scanlon MJ and Heras B (2018) Structural and biochemical insights into the disulfide reductase mechanism of DsbD, an essential enzyme for neisserial pathogens, J Biol Chem., 293(43): 16559-16571.

Smith RP, Whitten AE, Paxman JJ, Kahler CM, Scalon MJ and Heras B (2018) Production, biophysical characterization and initial crystallization studies of the n- and c- terminal domains of DsbD, an essential enzyme in Neisseria meningitidis, Acta Cryst F, F74: 31-38.

Totsika M, Vagenas D, Paxman JJ, Wang G, Dhouib R, Sharma P, Martin JL, Scanlon MJ and Heras B (2018) Inhibition of diverse DsbA enzymes in multi-DsbA encoding pathogens, Antioxid Redox Signal, 29(7): 653-666, doi: 10.1089/ars.2017.7104.

Furlong EJ, Lo AW, Kurth F, Premkumar P, Totsika M, Achard MES, Halili MA, Heras B, Whitten AE, Choudhury HG, Schembri MA and Martin JL (2017) A shape-shifting redox foldase contributes to Proteus mirabilis copper resistance, Nature Comm., 8: 16065.

Vo JL, Martínez Ortiz GC, Subedi P, Keerthikumar S, Mathivanan S, Paxman JJ and Heras B (2017) Autotransporter adhesins in Escherichia coli pathogenesis, Proteomics, 17(23-34), doi:10.1002/pmic.201600431.

Smith RP, Mohanty B, Williams ML, Scalon MJ and Heras B (2017) HN, N, Cα and Cβ assignments of the two periplasmic domains of Neisseria meningitidis DsbD, Biomol NMR Assign., 11(2): 181-186.

Paxman JJ and Heras B (2017) Bioinformatics tools and resources for analyzing protein structures, Methods Mol Biol., 1549: 209-20.

Christensen S, Grøftehauge MK, Byriel B, Huston WM, Furlong E, Heras B, Martin JL and McMahon RM (2016) Structural and biochemical characterization of chlamydia trachomatis DsbA reveals a cysteine-rich and weakly oxidising oxidoreductase, PLoS One., 11(12): e0168485.

Moriel DG, Heras B, Paxman JJ, LoAW, TanL, Sullivan MJ, Dando SJ, Beatson SA, Ulett GC and Schembri MA (2016) Molecular and structural characterisation of a novel Escherichia coli interleukin receptor mimic protein, mBio,7(2): e02046-15.

Smith RP, Paxman JJ, Scalon MJ and Heras B (2016) Targeting bacterial Dsb proteins for the development of anti-virulence agents, Molecules, 21(7): E811.

McMahon RM, Coincon M, Tay S, Heras B, Morton CJ, Scanlon MJ, Martin JL (2015) Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility, Acta Cryst Sect D, 71(Pt 12): 2386-95.

Adams LA, Sharma P, Mohanty B, Ilyichova OV, Mulcair MD, Williams ML, Gleeson EC, Totsika M, Doak BC, Caria S, Rimmer K, Horne J, Shouldice SR, Vazirani M, Headey SJ, Plumb BR, Martin JL, Heras B*, Simpson JS* and Scanlon MJ* (2015) Application of fragment-based screening to the design of inhibitors of Escherichia coli DsbA, Angew Chem Int Ed Engl., 54(7): 2179-84.

Heras B, Scanlon MJ and Martin JL (2015) Targeting virulence not viability in the search for future antibacterials, Br J Clin Pharmacol., 79(2): 208-15.

Heras B*, Totsika M, Peters KM, Paxman JJ, Gee C, Jarrott R, Perugini MA, Whitten AE and Schembri MA* (2014) The antigen 43 structure reveals a molecular Velcro-like mechanism of autotransporter-mediated bacterial clumping, Proc Natl Acad Sci USA, 111(1): 457-62.

Premkumar L, Kurth F, Duprez W, Groftehauge MK, King GJ, Halili MA, Heras B and Martin JL (2014) Structure of the Acinetobacter baumannii dithiol oxidase DsbA bound to elongation factor EF-Tu reveals a novel protein interaction site, J Biol Chem., 289(29): 19869-80.

Botello-Morte L, Bes MT, Heras B, Fernández-Otal A, Peleato ML and Fillat MF (2014) Unraveling the redox properties of the global regulator FurA from Anabaena sp. PCC 7120: disulfide reductase activity based on its CXXC motifs, Antioxid Redox Signal., 20(9): 1396-406.

Shepherd M*, Heras B*, Achard ME, King GJ, Argente MP, Kurth F, Taylor SL, Howard MJ, King NP, Schembri MA and McEwan AG (2013) Structural and functional characterization of ScsC, a periplasmic thioredoxin-like protein from Salmonella enterica serovar Typhimurium, Antioxid Redox Signal.,19(13): 1494-506.

Premkumar L, Heras B, Duprez W, Walden P, Halili M, Kurth F, Fairlie DP and Martin JL (2013) Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases, Acta Cryst Sect D Biol Crystallogr., 69(Pt 10): 1981-94.

Daly NL, Greenwood KP, King GJ, Rosengren KJ, Heras B, Martin JL and Craik DJ (2013) Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor, J Biol Chem., 288(50): 36141-48.

Kurth F, Premkumar L, Mohanty B, Duprez W, Halili MA, Shouldice SR, Heras B, Fairlie DP, Scanlon MJ and Martin JL (2013) Comparative sequence, structure and redox analyses of Klebsiella pneumoniae DsbA show that anti-virulence target DsbA enzymes fall into distinct classes, PLoS One, 8(11): e80210.

Nagpal J, Tan JL, Truscott KN, Heras B and Dougan DA (2013) Control of protein function through regulated protein degradation: biotechnological and biomedical applications, J Mol Microbiol Biotechnol., 23(4-5): 335-44.

*Contributed equally to work.