Infection and Immunity
The Infection and Immunity theme studies the molecules used by viruses, bacteria, parasites and fungi to infect humans, animals and plants, and the immune response associated with this and other immunological/cell biological events, such as stress and programmed cell death.
The overarching aim is to develop the next generation of antibiotic molecules to fight infection and to develop molecules that regulate cell death and combat inflammatory and autoimmune diseases.
Members have expertise in X-ray crystallography, mass spectrometry, enzymology, protein-protein interactions, gene transfection/transduction systems, cell phenotyping, flow cytometry and multi-colour cell sorting, confocal imaging, transgenic and gene-knockout models, human T cell culture and cloning, and monoclonal antibody production and generation.
Current projects include the role of complement and defensins in fighting bacterial and fungal infections; design of novel molecules to combat autoimmune conditions; migration and death of white blood cells in sepsis; and infection by viruses such as influenza and cytomegalovirus, and the immune response to them.