Theme Leader

Heras - Bacterial virulence factors: structure and function

Our group studies the molecular mechanisms underlying Gram-negative bacterial infections to develop antibacterial drugs that are not susceptible to existing resistance mechanisms.


Anderson - Plant innate immunity proteins

Our group works on protection of humans and crops from pathogens. We do this by studying natural defences of plants, and the biology of the pathogens themselves.

Binger - Immunometabolism and macrophage biology

Our research aims to understand the link between what immune cells ‘eat’ in our tissues and how this is connected to their normal biology and inflammatory diseases such as high blood pressure and diabetes.

Chen - T cell immunology

Our group specialises in CD8+ T cell biology and antigen processing and presentation, particularly in relation to the development of cross-protective immune responses to the influenza virus.

Dougan - Protein homeostasis in health and disease

Our group studies AAA+ proteases, responsible for general and regulated protein turn over in bacteria and in some organelles of eukaryotes.

Foley - Single domain antibodies in human disease

Our group uses single domain antibodies that have been developed from sharks to identify novel therapeutics against a number of chronic diseases.

Gras – Viral and structural immunology

Our laboratory is focused on understanding how to combat viral infections.

Hill - Neurodegenerative diseases, extracellular vesicles and noncoding RNAs

Our group uses a combination of biochemistry, molecular and cell biology to investigate neurodegenerative diseases such as Alzheimer's, Prion and Parkinson's diseases.

Hulett - Inflammation and tumour progression

Our group studies the molecular basis of tumour progression and inflammatory disease to develop novel anti-cancer and anti-inflammatory drugs.

Irving - Inflammation

Our group studies the molecular interactions in signal transduction networks regulating inflammation.

Keightley - Myeloid development and disease

Our group uses zebrafish models to discover and understand molecular pathways in blood cell development and disease.

Kettle - Autonomic and central nervous system regulation of metabolism

Our group examines the neurobiology and neurochemistry that underlies the physiology of metabolism.

Kvansakul - Structural biology of cell death and host-pathogen interactions

Our group examines how viruses hijack cellular defence systems to ensure their own proliferation and survival.

Orian - Neurodegenerative diseases

Our group uses proof-of-concept to identify pathological and molecular mechanisms of disease. We also evaluate candidate MS drugs.

O’Toole - Microbiology, molecular epidemiology

Our research group applies genomics for tracking the origin and spread of infectious diseases.

Poon - Apoptotic cell disassembly and clearance

Our group studies the machinery that control how dying cells can disassemble into smaller pieces, and the importance of cell disassembly in disease settings, to identify new drugs to control this process.

Puthalakath - Regulation of apoptosis by Bcl-2 family proteins

Our group researches the molecular basis of apoptosis regulation during heart failure, sepsis and in chemo resistance.

Tucci - Bacteriophage as alternatives to antibiotics, pharmacogenomics and pharmacy practice

Our group studies the use of bacteriophage as alternatives to antibiotics. We also examine the personalization of medicine to fit a patient's genetic profile, and patient management of medication in the treatment of chronic disease.

Van Dyke - Applied animal physiology

Our group studies animal models to discover novel mechanisms underlying reproductive, developmental, and immune functions.

Warr - Neural signalling

Our group investigate how cells in the nervous system receive and respond to signals from their environment.

Wijeyewickrema - Proteases, inhibitors and receptors: relationship to disease states

Our group researches enzymes, called proteases, which operate at the interface between a host, such as a human being and microbes that cause disease.