For a complete list of publications see:

Gruszczyk J, Kanjee U, Chan LJ, Menant S, Malleret B, Lim NTY, Schmidt CQ, Mok YF, Lin KM, Pearson RD, Rangel G, Smith BJ, Call MJ, Weekes MP, Griffin MDW, Murphy JM, Abraham J, Sriprawat K, Menezes MJ, Ferreira MU, Russell B, Renia L, Duraisingh MT and Tham WH (2018) Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax, Science, 359(6371): 48-55.

Glidden MD, Yang Y, Smith NA, Phillips NB, Carr K, Wickramasinghe NP, Ismail-Beigi F, Lawrence MC, Smith BG and Weiss MA  (2018) Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding, The Journal of Biological Chemistry, 293: 69-88.

Weiss MA, Phillips NF, Ismail-Beigi F, Pandyarajan V, Yang W, Chen YS, Wickramasinghe N, Smith B, Menting JG, Lawrence MC, El-Hage K and Meuwly M (2017) Non-Standard Protein Engineering at the Boundary of Molecular Mechanics and Quantum Chemistry: Halogen-Based Design of Insulin Analogs, Biophysical Journal, 112(3): 53a.

Brouwer JM, Lan P, Cowan AD, Bernardini JP, Birkinshaw RW, van Delft MF, Sleebs BE, Robin AY, Wardak A, Tan IK, Reljic B, Lee EF, Fairlie WD, Call MJ, Smith BJ, Dewson G, Lessene G, Colman PM and Czabotar PE (2017) Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design, Mol Cell., 68(4): 659-672.e9, doi: 10.1016/j.molcel.2017.11.001.

Johnson S, Rahmani R, Drew DR, Williams MJ, Wilkinson M, Tan YH, Huang JX, Tonkin CJ, Neeson JG, Baum J, Smith BJ* and Baell JB (2016) Truncated latrunculins as actin inhibitors targeting plasmodium falciparum motility and host cell invasion, J Med Chem., doi: 10.1021/acs.jmedchem.6b01109.

Hage KE, Pandyrarajan V, Phillips NB, Smith BJ, Meeting JG, Whittaker J, Lawrence MC, Meuwly M and Weiss MA (2016) Extending halogen-based medicinal chemistry to proteins: Iodo-insulin as a case study, J Biol Chem., doi: 10.1074/jbc.M116.761015.

Shahmiri M, Enciso M, Adda CG, Smith BJ, Perugini MA and Mechler A (2016) Membrane core-specific antimicrobial action of cathelicidon LL-37 peptide switches between pore and nanofibre formation, Sci Rep., 6: 38184.

Enciso M, Meftahi N, Walker ML and Smith BJ (2016) BioPPSy: an open-source platform for QSAR/QSPR analysis, PLoS One., 11: e0166298.

Meeting JG, Gajewaik J, MacRaild CA, Chou DH, Disotuar M, Smith NA, Miller C, Echegyi J, Rivier JE, Olivera BM, Forbes BE, Smith BJ, Norton RS, Safavi-Hemami H and Lawrence MC (2016) A minimized human insulin receptor binding motif is revealed in a venom insulin, Nat Struct Mol Biol., 23: 916-20.

Lawrence CF, Margets MB, Meeting JG, Smith NA, Smith BJ, Ward CW and Lawrence MC (2016) Insulin mimetic peptide disrupts the primary binding site of the insulin receptor, J Biol Chem., 291: 15473-81.

Lee EF, Grabow S, Chappaz S, Dewson G, Hockings C, Kluck RM, Gray DH, Witkowski MT, Evangelista M, Pettikiriarachchi A, Bouillet P, Lane RM, Czabotar PE, Colman PM, Smith BJ, Kile BT and Fairlie WD (2016) Physiological restraint of Bak by Bcl-xL is essential for cell survival, Genes Devel., 30: 1240-50.

Iyer S, Anwari K, Alsop AE, Yuen WS, Carroll J, Huang DCS, Smith NA, Smith BJ, Dewson G and Kluck RM (2016) Discovery of an activation site in Bak and mitochondrial Bax triggered by antibodies, Nat Commun, 7: 11734.

Croll TI, Smith BJ, Margets MB, Whittaker J, Weiss MA, Ward CW and Lawrence MC (2016) Higher-resolution structure of the human insulin receptor ectodomain: multi-modal inclusion of the insert domain, Structure, 24(3): 469-76.

Seoudi RS, Dowd A, Smith BJ and Mechler A (2016) Structural analysis of bioinspired nano-materials with synchrotron Far-IR spectroscopy, Phys Chem Chem Phys., 18: 11467-75.

Coffey MJ, Sleebs BE, Uboldi AD,Garnham A, Franco M, Marino ND, Panas M, Ferguson DLP, Enciso M, O'Neill MT, Lopaticki S, Stewart RJ, Dewson G, Smyth GK, Smith BJ, Masters SL, Boothroyd JC, Boddey JA and Tonkin CJ (2015) An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell, eLife, e10809.

Checco JW, Lee EF, Evangelista M, Sleebs NJ, Rogers K, Pettikiriarachchi A, Kershaw NJ, Eddinger GA, Belair DG, Wilson JL, Eller CH, Raines RT, Murphy WL, Smith BJ, Gellman SH and Fairlie WD (2015) a/b-peptide foldamers targeting intracellular protein-protein interactions with activity in living cells, J Am Chem Soc., 137(35): 11365-75.

Williams MJ, Alonso H, Enciso M, Egarter S, Shiener L, Meissner M, Striepen B, Smith BJ and Tonkin CJ (2015) Two essential light chains regulate MyoA lever arm to promote gliding motility in Toxoplasma gliding motility, MBio, 6(5): e00845-15.

Hodder AN, Sleebs BE, Czabotar PE, Gazdik M, Xu Y, O'Neill MT, Lopaticki S, Nebl T, Triglia T, Smith BJ, Lowes K, Boddey JA and Cowman AF (2015) Structural basis for plasmepsin V activity and inhibition that blocks export of malaria proteins to the host cell, Nat Struct Mol Biol., 22: 590-96.

Chang SC, Huq R, Chhabra S, Beeton C, Pennington M, Smith BJ and Norton R (2015) N-terminally extended analogues of the K+ channel toxin from Stichodatyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3., FEBS J., 282(12): 2247-59.

Iyer S, Bell F, Westphal D, Anwari K, Gulbis JM, Smith BJ, Dewson G and Kluck R (2015) Bak and Bax apoptotic pores involve juxtaposition of the C-terminal transmembrane domains, Cell Death Differ., 22(10): 1665-75.

Gazdik M, O'Neil MT, Lopaticki S, Lowes KN, Smith BJ, Cowman AF, Boddey JA and Sleebs BE (2015) The effect of N-methylation on transition state mimetic inhibitors of the Plasmodium protease, plasmepsin V., MedChemComm, 6: 437-43.

Pandyarajan V, Smith BJ, Phillips NB, Whittaker L, Cox GP, Wickramasinghe N, Menting JG, Wan Z-L, Whittaker J, Ismail-Beigi F, Lawrence MC and Weiss MA (2014) Aromatic anchor at an invariant hormone-receptor interface: function of insulin residue b24 with application to protein design, J Biol Chem., 289(5): 34709-27.

Chen L, Xu Y, Healer J, Thompson JK, Smith BJ, Nebl T, Lawrence MC and Cowman AF (2014) Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes, eLife, 3: e04187.

Westphal D, Dewson G, Menard M, Frederick P, Iyer S, Bartolo R, Gibson L, Czabotar PE, Smith BJ, Adams JM and Kluck RM (2014) Apoptotic pore formation is associated with in-plane insertion of Bak and Bax central helices into the mitochondrial outer membrane, Proc Nat Acad Sci USA, 111(39): e4076-85.

Sleebs BE, Gazdik M, O'Neill MT, Rajasekaran P, Lopaticki S, Lackovic K, Lowes K, Smith BJ, Cowman AF and Boddey JA (2014) Transition state mimetics of the Plasmodium export element are potent inhibitors of Plasmepsin V from P. falciparum and P. vivax, J Med Chem., 57(18): 7644-62.

Tao Z-F, Hasvold L, Wang L, Wang X, Petros AM, Park CH, Boghaert ER, Catron ND, Chen J, Colman PM, Czabotar PE, Deshayes K, Fairbrother WJ, Flygare JA, Hymowitz SG, Jin S, Judge RA, Koehler MFT, Kovar PJ, Lessene G, Mitten MJ, Ndubaku CO, Nimmer P, Purkey HE, Oleksijew A, Phillips DC, Sleebs BE, Smith BJ, Smith ML, Tahir SK, Watson KG, Xiao Y, Xue J, Zhang H, Zobel K, Rosenberg SH, Tse C, Leverson JD, Elmore SW and Souers AJ (2014) Discovery of a potent and selective BCL-XL inhibitor with In Vivo activity, ACS Med Chem Lett., 5(10): 1088-93.

Menting JG, Yang Y, Chan SJ, Phillips NB, Smith BJ, Whittaker J, Wickramasinghe NP, Whittaker L, Pandyarajan V, Wan Z-L, Yadav SP, Carroll JM, Strokes N, Roberts Jr. CT, Ismail-Beigi F, Milewski M, Steiner DF, Chauhan VS, Ward CW, Weiss MA and Lawrence MC (2014) Protective hinge in insulin opens to enable its receptor engagement, Proc Nat Acad Sci USA, 111(33): e3395-404.

Sleebs BE, Lopaticki S, Marapana DS, O'Neill MT, Rajasekaran P, Gazdik M, Gunther S, Whitehead LW, Lowes KN, Shaw PJ, Hodder AN, Smith BJ, Cowman AF and Boddey JA (2014) Inhibition of Plasmepsin V reveals it essential role in protein export, PfMEP1 surface display and survival of malaria parasites, PLoS Biol., 12(7): e1001897.

Koehler MFT, Bergeron P, Choo EF, Lau K, Ndubaku C, Dudley D, Sleebs BE, Rye CS, Nikolakopoulos G, Bui C, Kulasegaram S, Kersten WJA, Smith BJ, Czabotar PE, Colman PM, Huang DCS, Baell JB, Watson KG, Hasvold L, Tao Z-F, Wang L, Souers AJ, Elmore SW, Flygare JA, Fairbrother WJ and Lessene G (2014) Structure-guided rescaffolding of selective antagonists of BCL-XL, ACS Med Chem Lett., 5(6): 662-67.

Shahheydari H, Frost S, Smith BJ, Groblewski GE, Chen Y and Byrne JA (2014) Identification of PLP2 and RAB5C as novel TPD52 binding partners through yeast two-hybrid screening, Mol Biol Rep., 41(7): 4565-72.

Brady RM, Vom A, Roy MJ, Toovey N, Smith BJ, Moss RM, Hazis E, Huang DCS, Parisot JP, Yang H, Street IP, Colman PM, Czabotar PE, Baell JB and Lessene G (2014) De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization, J Med Chem., 57: 1323-43.

Okamoto T, Zobel K, Smith BJ, Fedorova A, Quan C, Yang H, Colman PM, Fairbrother WJ, Huang DCS, Deshayes K and Czabotar PE (2014) Further insights into the effects of pre-organizing the BimBH3 helix, ACS Chem Biol., 9(3): 838-39.

Leow CY, Willis C, Osman A, Mason L, Simon A, Gasser R, Smith BJ, Jones MK and Hofmann A (2014) Crystal structure and immunological properties of the first annexin from Schistosoma mansoni –  insights into the structural integrity of the schistosomal tegument, FEBS J., 281(4): 1209-25.

Smith BJ, Lee EF, Checco JW, Evangelista M, Gellman SH and Fairlie WD (2013) Structure-guided rational design of a/b-peptide foldamers with high affinity for Bcl-2 family pro-survival proteins, ChemBioChem, 14(13): 1564-72.

Lessene G, Czabotar PE, Sleebs BE, Zobel K, Lowes KL, Adams JM, Baell JB, Colman PM, Deshayes K, Fairbrother WJ, Flygare JA, Gibbons P, Kersten WJA, Kulasegaram S, Moss RM, Parisot JP, Smith BJ, Street JP, Yang H, Huang DCS and Watson KG (2013) Structure-guided design of a selective BCL-XL inhibitor, Nat Chem Biol., 9(6): 390-97.

Nguyen H, Galea CA, Smith BJ, Norton R and Chandy KG (2013) Intracellular trafficking of the Kv1.3 potassium channel is regulated by the pro-domain of a matrix metalloprotease, J Biol Chem., 288(9): 6451-64.

Czabotar PE, Westphal D, Dewson G, Ma S, Hockings C, Fairlie WD, Lee EF, Yao S, Robin AY, Smith BJ, Huang DCS, Kluck RM, Adams JM and Colman PM (2013) Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerisation to induce apoptosis, Cell, 152(3): 519-31.

Menting JG, Whittaker J, Margetts MB, Whitaker LJ, Kong GKW, Smith BJ, Watson CJ, Zakova L, Kletvikpva E, Jiracek J, Steiner DF, Chan SJ, Dodson GG, Brzozowski AM, Weiss MA, Ward CW and Lawrence MC (2013) How insulin engages its primary site on the insulin receptor, Nature, 493(7431): 241-45.

Okamoto T, Zobel K, Smith BJ, Fedorova A, Quan C, Yang H, Colman PM, Fairbrother WJ, Huang DCS, Deshayes K and Czabotar PE (2013) Stabilizing the helical BimBH3 peptide does not enhance binding affinity or biological activity, ACS Chem Biol., 8(2): 297-302.

Pell TA, Couchman SA, Ibrahim S, Wilson DJD, Smith BJ, Barnard PJ and Dutton JL (2012) Diverse reactions of PhI(OTf)2 with common 2-electron ligands: complex formation, oxidation and oxidative coupling, Inorg Chem., 51(23): 13034-40.

Nguyen HM, Miyazaki H, Hoshi N, Smith BJ, Nukina N, Goldin AL and Chandy KG (2012) Modulation of voltage-gated K+ channels by the sodium channel β1 subunit, Proc Nat Acad Sci USA, 109(45): 18577-82.

Hodder AN, Czabotar PE, Uboldi AD, Clarke OB, Lin CS, Healer J, Smith BJ and Cowman AF (2012) Insights into Duffy Binding-like domains through the crystal structure and function of the merozoite surface protein MSPDBL2 from Plasmodium falciparum, J Biol Chem., 287(39): 32922-39.

Smith BJ (2012) PS – a program for the analysis of helix geometry, J Mol Graphics Mod., 33: 52-60.

Boersma MD, Haase HS, Peterson-Kaufman KJ, Lee EF, Clarke OB, Colman PM, Smith BJ, Horne WS, Fairlie WD and Gellman SH (2012) Evaluation of diverse a/b backbone patterns for functional a-helix mimicry: analogues of the Bim BH3 domain, J Am Chem Soc., 134(1): 315-23.

* Corresponding co-author