COMPARE is a national randomised controlled trial recruiting 216 people with chronic aphasia (6 months to 15 years post-stroke) after single stroke and their primary carer/family member.
COMPARE is a three-arm prospective randomised controlled trial (RCT) and aims to:
- determine if two intensive and contrasting treatments – multi-modal aphasia therapy (M-MAT) and constraint induced aphasia therapy (CIAT) – result in better outcomes compared to the usual care aphasia treatments.
- define which individuals respond best to M-MAT and CIAT, based on the severity of aphasia and cognitive/linguistic profiles.
The efficacy of CIAT (Arm 1) and M-MAT (Arm 2) will be evaluated relative to the UC (Arm 3) in terms of:
- reduction in aphasia impairment as measured on standardised aphasia tests, and
- improvement in the accuracy and efficiency of connected speech in conversation.
This project will determine:
- patient characteristics associated with treatment response
- the most suitable treatment for particular patient sub-groups
- the longer-term efficacy of the interventions (at 12 weeks post treatment)
- the quality of life outcomes for people with aphasia, and
- the cost effectiveness of the interventions.
Design and method
Single blinded, three arm, prospective, randomised controlled trial.
This study will provide:
- the first large-scale, international standard RCT in chronic aphasia to examine outcomes from two potent but significantly different treatments, examining treatment response factors
- vital treatment prescription regimens equipping speech pathologists to provide optimal treatment, improve quality of life and reduce social isolation in people with chronic aphasia
- evidence that will underpin significant service delivery changes to enhance efficiency in aphasia-related rehabilitation expenditure, and improved patient outcomes.
- Associate Professor Miranda Rose (La Trobe University)
- Professor David Copland (The University of Queensland)
- Professor Lyndsey Nickels (Macquarie University)
- Professor Leanne Togher (The University of Sydney)
- Associate Professor Marcus Meinzer (The University of Queensland)
- Dr Tapan Rai (University of Technology, Sydney)
- Associate Professor Erin Godecke (Edith Cowan University)
- Associate Professor Dominique Cadilhac (Health Economics Consultancy; Monash University)
- Melanie Hurley
- Abby Foster
Expected date of completion