Reynolds - Self assembled nanomaterials
Self-assembled peptide nanofibrils as materials for 3D cell culture, bioprinting and tissue engineering.
We are exploring the applications of a variety of self-assembling nanofibrillar peptides, and their ability to act as 3D culture materials for a variety of cell types. These materials have applications in fundamental biology, tissue engineering and bioprinting.
Understanding the role of protein aggregation in diseases
Misfolded protein aggregates known as amyloid fibrils are the molecular hallmark of a number of neurodegenerative diseases including Alzheimer’s and Parkinson’s. However, protein misfolding and amyloid aggregation also play important roles in a number of other maladies that are not traditionally thought of as amyloid diseases. We are interested in studying the amyloid aggregation processes in some of these less well studied amyloid diseases. Currently, we have active projects investigating the role of amyloid assembly in inborn errors of metabolism such as Phenylketonuria (PKU), and investigating if amyloid assemblies are playing a role in some of the neurological symptoms that occur in COVID-19. These fundamental investigations will help us understand the molecular mechanisms that underpin the progression of these diseases, hopefully revealing new potential therapeutic targets that will aid the development of new drugs.