Cancer

The Cancer theme investigates the mechanisms of cancer initiation and progression, the crosstalk between cancer cells and the surrounding environment, and the potential of novel therapeutic approaches for combating disease.

Research spans the fields of cancer metastasis, cancer cell crosstalk with the microenvironment, pro- and anti-tumour immunity, and therapeutic sensitivity and resistance.

Current projects work to identify key drivers of cancer progression including secreted or exosomal factors; the targets, mechanisms of resistance and side effects of therapeutics; development of novel biomarkers for predicting cancer spread; and identification of ways that cancer cells co-opt the immune system to promote progression.

Members have expertise in in vivo bioluminescent and fluorescent imaging, confocal microscopy, fluorescence-activated cell sorting, 3D cell cultures, proteomic profiling, gene knockout/overexpression, DNA damage assessment, monitoring immune cell infiltration, activation and impact, stem cells, cancer cell invasion, EMT, and metastasis assays and DNA/RNA sequencing.