Publications

For a complete list of publications see:
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ResearchGate

Paxman JJ and Heras B* (2016) Bioinformatics tools and resources for analyzing protein structures, Methods Mol Biol., 1549: 209-20.

Christensen S, Grøftehauge MK, Byriel B, Huston WM, Furlong E, Heras B, Martin JL and McMahon RM (2016) Structural and biochemical characterization of chlamydia trachomatis DsbA reveals a cysteine-rich and weakly oxidising oxidoreductase, PLoS One., 11(12): e0168485.

Moriel DG, Heras B, Paxman JJ, LoAW, TanL, Sullivan MJ, Dando SJ, Beatson SA, Ulett GC and Schembri MA (2016) Molecular and structural characterisation of a novel Escherichia coli interleukin receptor mimic protein, mBio,7(2): e02046-15.

Smith RP, Paxman JJ, Scalon MJ and Heras B (2016) Targeting bacterial Dsb proteins for the development of anti-virulence agents, Molecules, 21(7): E811.

McMahon RM, Coincon M, Tay S, Heras B, Morton CJ, Scanlon MJ, Martin JL (2015) Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility, Acta Cryst Sect D, 71(Pt 12): 2386-95.

Adams LA, Sharma P, Mohanty B, Ilyichova OV, Mulcair MD, Williams ML, Gleeson EC, Totsika M, Doak BC, Caria S, Rimmer K, Horne J, Shouldice SR, Vazirani M, Headey SJ, Plumb BR, Martin JL, Heras B*, Simpson JS* and Scanlon MJ* (2015) Application of fragment-based screening to the design of inhibitors of Escherichia coli DsbA, Angew Chem Int Ed Engl., 54(7): 2179-84.

Heras B, Scanlon MJ and Martin JL (2015) Targeting virulence not viability in the search for future antibacterials, Br J Clin Pharmacol., 79(2): 208-15.

Heras B*, Totsika M, Peters KM, Paxman JJ, Gee C, Jarrott R, Perugini MA, Whitten AE and Schembri MA* (2014) The antigen 43 structure reveals a molecular Velcro-like mechanism of autotransporter-mediated bacterial clumping, Proc Natl Acad Sci USA, 111(1): 457-62.

Premkumar L, Kurth F, Duprez W, Groftehauge MK, King GJ, Halili MA, Heras B and Martin JL (2014) Structure of the Acinetobacter baumannii dithiol oxidase DsbA bound to elongation factor EF-Tu reveals a novel protein interaction site, J Biol Chem., 289(29): 19869-80.

Botello-Morte L, Bes MT, Heras B, Fernández-Otal A, Peleato ML and Fillat MF (2014) Unraveling the redox properties of the global regulator FurA from Anabaena sp. PCC 7120: disulfide reductase activity based on its CXXC motifs, Antioxid Redox Signal., 20(9): 1396-406.

Shepherd M*, Heras B*, Achard ME, King GJ, Argente MP, Kurth F, Taylor SL, Howard MJ, King NP, Schembri MA and McEwan AG (2013) Structural and functional characterization of ScsC, a periplasmic thioredoxin-like protein from Salmonella enterica serovar Typhimurium, Antioxid Redox Signal.,19(13): 1494-506.

Premkumar L, Heras B, Duprez W, Walden P, Halili M, Kurth F, Fairlie DP and Martin JL (2013) Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases, Acta Cryst Sect D Biol Crystallogr., 69(Pt 10): 1981-94.

Daly NL, Greenwood KP, King GJ, Rosengren KJ, Heras B, Martin JL and Craik DJ (2013) Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor, J Biol Chem., 288(50): 36141-48.

Kurth F, Premkumar L, Mohanty B, Duprez W, Halili MA, Shouldice SR, Heras B, Fairlie DP, Scanlon MJ and Martin JL (2013) Comparative sequence, structure and redox analyses of Klebsiella pneumoniae DsbA show that anti-virulence target DsbA enzymes fall into distinct classes, PLoS One, 8(11): e80210.

Nagpal J, Tan JL, Truscott KN, Heras B and Dougan DA (2013) Control of protein function through regulated protein degradation: biotechnological and biomedical applications, J Mol Microbiol Biotechnol., 23(4-5): 335-44.

Walden PW, Heras B, Chen KE, Halili M, Rimmer K, Sharma P, Scanlon MJ and Martin JL (2012) The 1.2 Å resolution crystal structure of TcpG, the Vibrio cholerae DsbA disulfide-forming protein required for pilus and cholera-toxin production, Acta Cryst Sect D., 68(Pt 10): 1290-302.

King NP, Sakinc T, Ben Zakour NL, Totsika M, Heras B, Simerska P, Shepherd M, Gatermann SG, Beatson SA and Schembri MA (2012) Characterisation of a cell wall-anchored protein of Staphylococcus saprophyticus associated with linoleic acid resistance, BMC Microbiol., 12:8, doi: 10.1186/1471-2180-12-8.

Shouldice SR, Heras B, Walden PW, Totsika M, Schembri MA and Martin JL (2011) Structure and function of DsbA, a key bacterial oxidative folding catalyst, Antioxid Redox Signal.,14(9): 1729-60.

*Contributed equally to work.