Microbial Genetics and Interactions Research

This project aims to isolate phages responsible for the lysis of probiotic bacteria in the gut. Our preliminary data suggests that guts from hypertensive mice have an over-abundance of phages that lyse the probiotic bacteria, Faecalibacterium. We are currently trying to isolate phages from cultures of Faecalibacterium to prove that they are capable of disturbing the micriobiome and promoting hypertension in mice. Once this is established we then plan to devise strategies aimed at eliminating these phages from the gut environment in order to restore a healthy microbiome.

During routine screening of phages, our group serendipitously discovered at least five bacteria that behave like phages. These bacteria are small parasitic organisms that have lytic ability against their host bacteria, just like phages. This project aims to characterise the molecular mechanisms involved in the interactions of these parasitic bacteria with their hosts. Understanding these mechanism could lead to the development of novel antibiotic therapies for the treatment of human diseases.

This project investigates ways in which antibiotic resistance genes move from one bacterial cell to another. Antibiotic resistance genes are naturally found in certain bacteria and encode proteins that allow them to move from one cell to another. The project seeks to understand the molecular mechanisms involved in the movement of such ‘mobile genetic elements’ and to determine ways in which we can prevent their movement. This could lead to novel ways to reduce the emergence and spread of antibiotic-resistant bacterial strains through the community.