Truscott - Mitochondrial protein homeostasis
Dr Kaye Truscott
Senior Lecturer, College of Science, Health and Engineering
Many neurodegenerative diseases have a devastating impact on the quality of life for patients and constitute a significant burden for families and the healthcare system. Although a large and diverse group of diseases, symptoms can include memory loss, cognitive impairment and a decline in motor control. Currently there are limited treatment options and in many cases there is only a rudimentary understanding of the primary cause of these diseases and the molecular events that lead to disease.
It is very apparent that mitochondrial dysfunction is associated with a significant number of neurodegenerative diseases. Many genes mutated in patients with a neurological disease are required for mitochondrial biogenesis, function or maintenance. Research in our laboratory aims to understand, at a molecular level, the function of mitochondrial proteins involved in the biogenesis and maintenance of mitochondria. It is anticipated that new knowledge in this area will aid in the development of effective ways to treat neurodegenerative diseases.