Adam Mechler group
Nanochemistry, self-assembling nanosystems, biomembranes, antimicrobial peptides
At the heart of Professor Adam Mechler's research is a fascination with how molecules organise themselves into complex structures to build something far more elaborate than any single piece. molecular self-assembly underpins many of the key biochemical processes, from the formation of cell membranes through the strength of silk fibres to the complex operation of the flagellum rotor. Taking inspiration from this complexity, Prof Mechler translates the solutions offered by nature into intricate molecular systems, built and maintained without the formation of a single covalent bond.
Research areas
Phospholipids, the molecules that make up cell membranes, naturally arrange themselves into precise, functional structures that act as the boundary of every living cell. By studying how these membranes are built — and how certain antimicrobial peptides (small proteins found in nature) can punch holes in or disrupt them — we can learn how to design the next generation of antibiotics and antiviral drugs, and even safer, organic-based treatments that protect crop seeds from fungal and bacterial infection without harming the surrounding ecosystem. This is critically important at a time when food security and antibiotic resistance are the greatest threats to global health.
Metallosupramolecular frameworks are based on the self-assembly of specifically designed matching molecules, — much like how LEGO bricks snap together — to form intricate hierarchical structures. These can be designed to carry drugs, sense pathogens, or form the basis of molecular-scale electronic components. These ideas translate into a surprisingly broad range of practical applications: coatings that prevent bacteria from colonising ship hulls or medical implants (anti-biofouling), smart surface treatments for aerospace materials that can respond to their environment.
Meet the team
Group leader:
- Professor Adam Mechler
Postdoctoral researchers:
- Dr Dani Wiles
PhD researchers:
- Yifan Wang
- Khadeeja Husein
- Bhavesha Chanchlani
- Lachlan Preshaw
- Arunima Das