Orian - Neurodegenerative diseases
Dr Jacqueline Orian
, College of Science, Health and Engineering
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) affecting over two million individuals worldwide. It is a major cause of neurodegeneration in young adults, but can also first manifest in late middle age or during childhood. Its aetiology is unknown, however genetic predisposition and environmental factors are known to contribute significantly to disease development. MS exists as a number of sub-types differentiated by age of onset and frequency and severity of episodes of neurological deficits.
It was originally thought that MS was a disease of the CNS white matter (wm), but it is now apparent that the grey matter (gm) is also affected from the earliest disease stage. Using the animal model for MS known as experimental autoimmune encephalomyelitis (EAE), we aim to generate proof-of-concept for pathological and molecular mechanisms underlying the disease and to evaluate candidate MS drugs.