PHARMACOLOGY B

PHA2PGB

2020

Credit points: 15

Subject outline

This subject will introduce you to how variation in human molecular genetics may affect the pharmacokinetics and pharmacodynamics of drugs. Examples will focus on mutations associated with altered drug metabolism, excretion and potential for toxicity. Immune responses from a cellular and molecular perspective will be introduced incorporating innate immunity, inflammation, chemical cascades, adaptive immunity and cells of the immune system. Within this context immunopharmacology and immunotherapy will also be explored.


SchoolSchool of Molecular Sciences/LIMS

Credit points15

Subject Co-ordinatorCristina Keightley

Available to Study Abroad StudentsYes

Subject year levelYear Level 2 - UG

Exchange StudentsYes

Subject particulars

Subject rules

Prerequisites BIO1CO or BIO1OF or BIO1MGC or BIO1OOS

Co-requisitesN/A

Incompatible subjectsN/A

Equivalent subjectsN/A

Special conditionsN/A

Readings

Resource TypeTitleResource RequirementAuthor and YearPublisher
ReadingsPrinciples of Pharmacogenetics and PharmacogenomicsRecommendedAltman RB, Flockhart D, Goldstein DB (ed) 2012Cambridge Core.
ReadingsBasic Immunology: Functions and disorders of the immune systemRecommendedAbbas, A B, Lichtman, A H6th ed Elsevier

Graduate capabilities & intended learning outcomes

01. Use an understanding of the variability within and between populations to interpret effects on drug metabolism.

Activities:
The impact of variability within and between populations will be examined in lectures and reinforced in tutorials. Understanding will be assessed in the mid- semester test and final examination.
Related graduate capabilities and elements:
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)
Inquiry and Analytical Skills (Critical Thinking,Creative Problem-solving,Inquiry/Research)
Discipline -Specific Knowledge and Skills (Discipline-Specific Knowledge and Skills)

02. Evaluate how the variability in pharmacogenetics can cause toxic levels of drugs to circulate.

Activities:
The influence of variability in pharmacogenetics on toxicity levels will be explained in lectures and reinforced in tutorials. Understanding will be assessed in the mid- semester test and final examination.
Related graduate capabilities and elements:
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)
Inquiry and Analytical Skills (Critical Thinking,Creative Problem-solving,Inquiry/Research)
Inquiry and Analytical Skills (Critical Thinking,Creative Problem-solving,Inquiry/Research)
Discipline -Specific Knowledge and Skills (Discipline-Specific Knowledge and Skills)

03. Assess different causes of pharmaceutical toxicity including physiological change during human development, as a result of drug overdose or in a range of diseases

Activities:
Causes of toxicity will be explained in lectures and reinforced in tutorials. Understanding will be assessed in the mid- semester test and final examination.
Related graduate capabilities and elements:
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)
Inquiry and Analytical Skills (Critical Thinking,Creative Problem-solving,Inquiry/Research)
Discipline -Specific Knowledge and Skills (Discipline-Specific Knowledge and Skills)

04. Explain the process of inflammation and the steps involved in initiation of the immune response to analyse drug interactions with the immune system.

Activities:
Inflammation and immune recognition systems will be presented in lectures. Understanding will be assessed in online quizzes and the final examination.
Related graduate capabilities and elements:
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)
Inquiry and Analytical Skills (Critical Thinking,Creative Problem-solving,Inquiry/Research)
Inquiry and Analytical Skills (Critical Thinking,Creative Problem-solving,Inquiry/Research)
Personal and Professional Skills (Teamwork including leadership and working in groups,Ethical behaviour)
Discipline -Specific Knowledge and Skills (Discipline-Specific Knowledge and Skills)

05. Discuss how immunogenetics gives rise to clonal variation to fight infection and how immunopharmacotherapies can be used to target disease.

Activities:
Immunogenetics and immunopharmacology will be presented during class time. Understanding will be assessed in online quizzes and the final examination..
Related graduate capabilities and elements:
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)
Discipline -Specific Knowledge and Skills (Discipline-Specific Knowledge and Skills)

Subject options

Select to view your study options…

Start date between: and    Key dates

Albury-Wodonga, 2020, Semester 2, Day

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Enrolment information

Subject Instance Co-ordinatorCathryn Hogarth

Class requirements

Lecture Week: 31 - 43
Two 1.0 hours lecture per week on weekdays during the day from week 31 to week 43 and delivered via face-to-face.
"24-hours of Blended Lectures and Online Learning Activities in the teaching period delivered as a combination of face-to-face and online."

Tutorial Week: 31 - 43
One 2.0 hours tutorial per week on weekdays during the day from week 31 to week 43 and delivered via face-to-face.
"24-hours of Tutorial or Directed Learning Activities during the teaching period and delivered via face-to-face or online."

Assessments

Assessment elementComments% ILO*
2-hour end of semester written examination (2,000-words equivalent)50 01, 02, 03, 04, 05
1-hour mid-semester test (1,000 words equivalent)15 01, 02, 03
One group review article (750-words per student)25 01, 02, 03
3 x online tests during semester (500-words equivalent)10 01, 02, 03, 04, 05

Bendigo, 2020, Semester 2, Day

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Enrolment information

Subject Instance Co-ordinatorCristina Keightley

Class requirements

Lecture Week: 31 - 43
Two 1.0 hours lecture per week on weekdays during the day from week 31 to week 43 and delivered via face-to-face.
"24-hours of Blended Lectures and Online Learning Activities in the teaching period delivered as a combination of face-to-face and online."

Tutorial Week: 31 - 43
One 2.0 hours tutorial per week on weekdays during the day from week 31 to week 43 and delivered via face-to-face.
"24-hours of Tutorial or Directed Learning Activities during the teaching period and delivered via face-to-face or online. "

Assessments

Assessment elementComments% ILO*
2-hour end of semester written examination (2,000-words equivalent)50 01, 02, 03, 04, 05
1-hour mid-semester test (1,000 words equivalent)15 01, 02, 03
One group review article (750-words per student)25 01, 02, 03
3 x online tests during semester (500-words equivalent)10 01, 02, 03, 04, 05

Singapore (PSB), 2020, Term L1, Day

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Enrolment information

Subject Instance Co-ordinatorJennifer Selkirk-Bell

Class requirements

Lecture Week: 02 - 07
One 36.0 hours lecture per study period on weekdays during the day from week 02 to week 07 and delivered via face-to-face.
"36-hours of Blended Lectures and Online Learning Activities in the teaching period delivered as a combination of face-to-face and online."

Tutorial Week: 02 - 07
One 12.0 hours tutorial per study period on weekdays during the day from week 02 to week 07 and delivered via face-to-face.
"12-hours of Tutorial or Directed Learning Activities during the teaching period and delivered via face-to-face or online."

Assessments

Assessment elementComments% ILO*
2-hour end of semester written examination (2,000-words equivalent)50 01, 02, 03, 04, 05
1-hour mid-semester test (1,000 words equivalent)15 01, 02, 03
One group review article (750-words per student)25 01, 02, 03
3 x online tests during semester (500-words equivalent)10 01, 02, 03, 04, 05

Singapore (PSB), 2020, Term 2, Day

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Enrolment information

Subject Instance Co-ordinatorJennifer Selkirk-Bell

Class requirements

Lecture Week: 21 - 31
Twenty four 1.0 hours lecture per study period on weekdays during the day from week 21 to week 31 and delivered via face-to-face.
"24-hours of Blended Lectures and Online Learning Activities in the teaching period delivered as a combination of face-to-face and online."

Tutorial Week: 21 - 31
Twenty four 1.0 hours tutorial per study period on weekdays during the day from week 21 to week 31 and delivered via face-to-face.
"24-hours of Tutorial or Directed Learning Activities during the teaching period and delivered via face-to-face or online."

Assessments

Assessment elementComments% ILO*
2-hour end of semester written examination (2,000-words equivalent)50 01, 02, 03, 04, 05
1-hour mid-semester test (1,000 words equivalent)15 01, 02, 03
One group review article (750-words per student)25 01, 02, 03
3 x online tests during semester (500-words equivalent)10 01, 02, 03, 04, 05

Singapore (PSB), 2020, Term 2, Night

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Enrolment information

Subject Instance Co-ordinatorJennifer Selkirk-Bell

Class requirements

Tutorial Week: 21 - 31
Twenty four 1.0 hours tutorial per study period on weekdays at night from week 21 to week 31 and delivered via face-to-face.
"24-hours of Tutorial or Directed Learning Activities during the teaching period and delivered via face-to-face or online."

Lecture Week: 21 - 31
Twenty four 1.0 hours lecture per study period on weekdays at night from week 21 to week 31 and delivered via face-to-face.
"24-hours of Blended Lectures and Online Learning Activities in the teaching period delivered as a combination of face-to-face and online."

Assessments

Assessment elementComments% ILO*
2-hour end of semester written examination (2,000-words equivalent)50 01, 02, 03, 04, 05
1-hour mid-semester test (1,000 words equivalent)15 01, 02, 03
One group review article (750-words per student)25 01, 02, 03
3 x online tests during semester (500-words equivalent)10 01, 02, 03, 04, 05