MEDICINAL AND ORGANIC CHEMISTRY

CHE2MOC

2020

Credit points: 15

Subject outline

In this subject you will be introduced to medicinal chemistry, with an emphasis on how drugs interact with their molecular targets of lipids, carbohydrates, nucleic acids and proteins. A key aspect is to develop understanding of organic chemistry, where you will focus on the properties, nomenclature, reactions and mechanisms of key functional groups used in organic synthesis, including the critical concept of stereochemistry. You will gain experience conducting and interpreting laboratory experiments related to the synthesis of organic and molecules with a focus on medicinal drug design.



SchoolSchool of Molecular Sciences/LIMS

Credit points15

Subject Co-ordinatorYuning Hong

Available to Study Abroad StudentsYes

Subject year levelYear Level 2 - UG

Exchange StudentsYes

Subject particulars

Subject rules

Prerequisites CHE1APL and (CHE1CHF or CHE1GEN)

Co-requisitesN/A

Incompatible subjectsN/A

Equivalent subjectsN/A

Special conditionsN/A

Readings

Resource TypeTitleResource RequirementAuthor and YearPublisher
ReadingsIntroduction to Medicinal ChemistryPrescribedPatrick, G., 2013Oxford University Press
ReadingsOrganic ChemistryPrescribedMcMurry, J., 2016Thomson-Brooks/Cole

Graduate capabilities & intended learning outcomes

01. Explain the fundamental concepts of medicinal chemistry.

Activities:
During lectures students will answer short questions individually or as part of small groups, reinforcing the lecture material. Students will also work through problems that reinforce the concepts associated with this ILO individually. This material will be covered in tutorials and students will be required to orally explain their answers and participate in tutorial discussions. Written tasks and online quizzes will be will be used to reinforce and assess this ILO.

02. Illustrate understanding of the ways drugs interact with their molecular targets.

Activities:
During lectures students will answer short questions individually or as part of small groups, reinforcing lecture material. Written tasks and online quizzes will be used to reinforce and assess the concepts associated with this ILO.

03. Employ concepts of bonding to explain the properties of organic compounds.

Activities:
Students will work through problems that reinforce the concepts associated with this ILO individually. During lectures students will answer short questions individually or as part of small groups. This material will also be covered in workshops and students will be required to orally explain their answers and participate in discussions. Written worksheets and in class testing will be used to reinforce and assess this ILO.

04. Design synthetic schemes for the preparation of organic compounds showing understanding of reaction mechanisms.

Activities:
During lectures students will answer short questions individually or as part of small groups, reinforcing lecture material. The concepts associated with this ILO will be reinforced using online quizzes, administered using LMS. Written worksheets and in class testing will be used to reinforce and assess this ILO.

05. Demonstrate practical skills needed to conduct chemical synthesis, chemical analysis and be able to interpret and report the results of spectroscopic measurements.

Activities:
Working individually or in small groups students will aquire practical skills required for the manipulation of chemicals for chemical synthesis. Working individually or in small groups students will learn techniques (chemical and instrumental) used in modern chemical analysis. Working individually or in small groups students will learn how to make spectroscopic measurements. Students will develop skills in the preparation of laboratory reports, including the use of correct and appropriate prose and presentation of experimental data and results.

Subject options

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Start date between: and    Key dates

Melbourne, 2020, Semester 1, Day

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Enrolment information

Subject Instance Co-ordinatorYuning Hong

Class requirements

Laboratory Class Week: 11 - 13
One 3.0 hours laboratory class per week on weekdays during the day from week 11 to week 13 and delivered via face-to-face.
"The laboratory program consists of 6 classes and additional learning activities (3 hours each) over the semester. A schedule of experiments will be made available to students on the LMS at the start of semester."

Lecture Week: 10 - 22
Two 1.0 hours lecture per week on weekdays during the day from week 10 to week 22 and delivered via face-to-face.

Tutorial Week: 10 - 22
One 1.0 hours tutorial per week on weekdays during the day from week 10 to week 22 and delivered via face-to-face.

Seminar Week: 10 - 10
One 3.0 hours seminar per week on weekdays during the day from week 10 to week 10 and delivered via face-to-face.
"Laboratory safety introduction will be held in the first week of semester."

Laboratory Class Week: 10 - 22
One 3.0 hours laboratory class per week on weekdays during the day from week 10 to week 22 and delivered via face-to-face.
"The laboratory program consists of 6 classes and additional learning activities (3 hours each) over the semester. A schedule of experiments will be made available to students on the LMS at the start of semester."

Assessments

Assessment elementComments% ILO*
Online quizzes (500 words equiv)Two LMS quizzes during semester.10 01, 02
Laboratory work and reports (1500 words equivalent)Hurdle for accreditation with RACI. Students must complete a minimum 75% of lab assessment, and must obtain a score of at least 50% for the laboratory component of the subject.30 03, 04, 05
Test (500 words equivalent)One in class test during semester10 03, 04
Examinations (2 x 1 hour exams) or equivalent assessment tasks during semesterTwo 1 hour papers in the central examination period or equivalent assessment tasks during semester. Students can select either option. 50 01, 02, 03, 04