MEDICINAL CHEMISTRY A

CHE2MCA

2021

Credit points: 15

Subject outline

Students will be introduced to the chemical principles that are required to understand the action and behaviours of a drug compound. The main areas of study include an introduction to the chemistry and nomenclature of carbohydrates, lipids, steroids and heterocyclic compounds and some of their reactions. This unit will provide an understanding of how the chemical structure and behaviour of drug molecules relate to the activity of drugs in biological systems, and how this knowledge can be used to devise strategies for drug design and principles of drug structure-activity relationships (SAR and QSAR), drug-receptor interactions and drugs metabolism. This unit will also contain a computer based practical component.

SchoolMolecular Sciences

Credit points15

Subject Co-ordinatorJasim Al-Rawi

Available to Study Abroad/Exchange StudentsYes

Subject year levelYear Level 2 - UG

Available as ElectiveNo

Learning ActivitiesN/A

Capstone subjectNo

Subject particulars

Subject rules

Prerequisites(CHE1C1B AND CHE1C1A) OR (CHE1CHF AND CHE1APL)

Co-requisitesN/A

Incompatible subjectsN/A

Equivalent subjectsN/A

Quota Management StrategyN/A

Quota-conditions or rulesN/A

Special conditionsN/A

Minimum credit point requirementN/A

Assumed knowledgeN/A

Learning resources

Organic chemistry

Resource TypeBook

Resource RequirementPrescribed

AuthorBruice, P. Y.

Year2017

Edition/VolumeN/A

PublisherPearson

ISBNN/A

Chapter/article titleN/A

Chapter/issueN/A

URLN/A

Other descriptionN/A

Source locationN/A

An Introduction to Medicinal Chemistry

Resource TypeBook

Resource RequirementPrescribed

AuthorPatrick, G.

Year2013

Edition/VolumeN/A

PublisherOxford University Press

ISBNN/A

Chapter/article titleN/A

Chapter/issueN/A

URLN/A

Other descriptionN/A

Source locationN/A

Medicinal Chemistry: An Introduction

Resource TypeBook

Resource RequirementRecommended

AuthorThomas, G.

Year2007

Edition/VolumeN/A

PublisherWiley

ISBNN/A

Chapter/article titleN/A

Chapter/issueN/A

URLN/A

Other descriptionN/A

Source locationN/A

Career Ready

Career-focusedNo

Work-based learningNo

Self sourced or Uni sourcedN/A

Entire subject or partial subjectN/A

Total hours/days requiredN/A

Location of WBL activity (region)N/A

WBL addtional requirementsN/A

Graduate capabilities & intended learning outcomes

Graduate Capabilities

Intended Learning Outcomes

01. Apply understanding of the chemistry of important biological molecules such as carbohydrates, lipids, steroids and heterocyclic molecules to medicinal products.
02. Apply advanced understanding of the chemistry of organic compounds and its impact on syntheses to enhance drug efficacy.
03. Use the major concepts and language of pharmaceutical and medicinal chemistry correctly.
04. Determine likely routes of administration through recognition of drug structures, identification and prediction of likely metabolic and elimination pathways, solubility and metabolism.
05. Devise strategies for drug design and principles of drug structure-activity relationships (SAR and QSAR).

Subject options

Select to view your study options…

Start date between: and    Key dates

Singapore (PSB), 2021, Term 1, Day

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Subject Instance Co-ordinatorJennifer Selkirk-Bell

Class requirements

Computer LaboratoryWeek: 4 - 15
One 3.00 hours computer laboratory per study period on weekdays during the day from week 4 to week 15 and delivered via face-to-face.

LectureWeek: 4 - 15
Thirty six 1.00 hour lecture per study period on weekdays during the day from week 4 to week 15 and delivered via face-to-face.
36-hours of Blended Lectures and Online Learning Activities in the teaching period delivered as a combination of face-to-face and online.

PracticalWeek: 4 - 15
One 3.00 hours practical per study period on weekdays during the day from week 4 to week 15 and delivered via face-to-face.

TutorialWeek: 4 - 15
Twelve 1.00 hour tutorial per study period on weekdays during the day from week 4 to week 15 and delivered via face-to-face.
12-hours of tutorials or online quizzes during the teaching period and delivered via face-to-face or online.

Assessments

Assessment elementCommentsCategoryContributionHurdle% ILO*

One 3-hour end-of-semester written examination (3,000-words equivalent)

N/ACentral examIndividualNo60 SILO1, SILO2, SILO3, SILO4, SILO5

Two in-class tests (15% each) (600-words equivalent in total)

N/AQuizzesIndividualNo30 SILO1, SILO2, SILO3

Two laboratory reports (5% each) (300-words equivalent in total)

N/AReportIndividualNo10 SILO2, SILO3

Singapore (PSB), 2021, Term 2, Day

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Subject Instance Co-ordinatorJennifer Selkirk-Bell

Class requirements

Computer LaboratoryWeek: 21 - 31
One 3.00 hours computer laboratory per study period on weekdays during the day from week 21 to week 31 and delivered via face-to-face.

LectureWeek: 21 - 31
Thirty six 1.00 hour lecture per study period on weekdays during the day from week 21 to week 31 and delivered via face-to-face.
36-hours of Blended Lectures and Online Learning Activities in the teaching period delivered as a combination of face-to-face and online.

PracticalWeek: 21 - 31
One 3.00 hours practical per study period on weekdays during the day from week 21 to week 31 and delivered via face-to-face.

TutorialWeek: 21 - 31
Twelve 1.00 hour tutorial per study period on weekdays during the day from week 21 to week 31 and delivered via face-to-face.
12-hours of tutorials or online quizzes during the teaching period and delivered via face-to-face or online.

Assessments

Assessment elementCommentsCategoryContributionHurdle% ILO*

One 3-hour end-of-semester written examination (3,000-words equivalent)

N/ACentral examIndividualNo60 SILO1, SILO2, SILO3, SILO4, SILO5

Two in-class tests (15% each) (600-words equivalent in total)

N/AQuizzesIndividualNo30 SILO1, SILO2, SILO3

Two laboratory reports (5% each) (300-words equivalent in total)

N/AReportIndividualNo10 SILO2, SILO3

Singapore (PSB), 2021, Term 2, Night

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Subject Instance Co-ordinatorJennifer Selkirk-Bell

Class requirements

Computer LaboratoryWeek: 21 - 31
One 3.00 hours computer laboratory per study period on weekdays at night from week 21 to week 31 and delivered via face-to-face.

LectureWeek: 21 - 31
Thirty six 1.00 hour lecture per study period on weekdays at night from week 21 to week 31 and delivered via face-to-face.
36-hours of Blended Lectures and Online Learning Activities in the teaching period delivered as a combination of face-to-face and online.

PracticalWeek: 21 - 31
One 3.00 hours practical per study period on weekdays at night from week 21 to week 31 and delivered via face-to-face.

TutorialWeek: 21 - 31
Twelve 1.00 hour tutorial per study period on weekdays at night from week 21 to week 31 and delivered via face-to-face.
12-hours of tutorials or online quizzes during the teaching period and delivered via face-to-face or online.

Assessments

Assessment elementCommentsCategoryContributionHurdle% ILO*

One 3-hour end-of-semester written examination (3,000-words equivalent)

N/ACentral examIndividualNo60 SILO1, SILO2, SILO3, SILO4, SILO5

Two in-class tests (15% each) (600-words equivalent in total)

N/AQuizzesIndividualNo30 SILO1, SILO2, SILO3

Two laboratory reports (5% each) (300-words equivalent in total)

N/AReportIndividualNo10 SILO2, SILO3

Singapore (PSB), 2021, Term 3, Day

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Subject Instance Co-ordinatorJennifer Selkirk-Bell

Class requirements

Computer LaboratoryWeek: 37 - 47
One 3.00 hours computer laboratory per study period on weekdays during the day from week 37 to week 47 and delivered via face-to-face.

LectureWeek: 37 - 47
Thirty six 1.00 hour lecture per study period on weekdays during the day from week 37 to week 47 and delivered via face-to-face.
36-hours of Blended Lectures and Online Learning Activities in the teaching period delivered as a combination of face-to-face and online.

PracticalWeek: 37 - 47
One 3.00 hours practical per study period on weekdays during the day from week 37 to week 47 and delivered via face-to-face.

TutorialWeek: 37 - 47
Twelve 1.00 hour tutorial per study period on weekdays during the day from week 37 to week 47 and delivered via face-to-face.
12-hours of tutorials or online quizzes during the teaching period and delivered via face-to-face or online.

Assessments

Assessment elementCommentsCategoryContributionHurdle% ILO*

One 3-hour end-of-semester written examination (3,000-words equivalent)

N/ACentral examIndividualNo60 SILO1, SILO2, SILO3, SILO4, SILO5

Two in-class tests (15% each) (600-words equivalent in total)

N/AQuizzesIndividualNo30 SILO1, SILO2, SILO3

Two laboratory reports (5% each) (300-words equivalent in total)

N/AReportIndividualNo10 SILO2, SILO3