Cardiovascular Physiology

The cardiovascular laboratory led by Dr Colleen Thomas uses integrative physiological approaches to characterise and develop new drugs and strategies to reduce cardiovascular disease. Autonomic neuroscience and motor neurone disease constitute other areas of current interest.  

Key projects in animals and humans include:

  1. Mediterranean diet: an intervention to reduce secondary acute myocardial infarction (funded by Understanding Disease RFA)
  2. Protective mechanism of remote limb ischaemic preconditioning against myocardial ischemia -reperfusion injury (funded by Understanding Disease RFA)
  3. Cognitive decline (and neuroinflammation) in Type 2 diabetes 
    1. dietary intervention with omega 3 fatty acids
    2. analysis of the Australian Longitudinal Studies on Women's Health (ALSWH) data. Key personnel includes Drs  Jency Thomas and Amy Larsen (Masters student, Mr Oliver Butt)
  4. Contribution of the area postrema to the heart failure condition (PhD student, Yonis Abukar)
  5. Developing Protein Disulphide Isomerase (PDI) and its molecular mimics as a novel therapeutic model in motor neurone disease (PhD student, Emma Perri).
  6. Effects of ageing on autonomic reflex control of the heart