Bacteriophages evolution, genomics and therapy
Bacteriophages are the most abundant biological entities on the planet, yet very few of their genomes have been completely sequenced. With the availability of next generation DNA sequencing the number of phage genomes sequenced is increasing rapidly. Analyses of these sequences provides a better understanding of their evolutionary interrelationships. We are particularly interested in actinophage genomics and applying Illumina technology sequencing to novel genomes.
With the increasing emergence of antibiotic resistance we are now entering an era where other methods are being looked at to control serious bacterial infections. Bacteriophage therapy is one such approach. Research is being conducted in collaboration with Dr Joseph Tucci from the School of Pharmacy at La Trobe University to isolate and characterize novel phages for incorporation into topical pharmaceuticals for fighting topical bacterial infections.