Synthesis and docking of 7-substituted-8-aryl-2-morpholino-1,3-benzoxazine as a selective PDE3 inhibition

Cyclic nucleotides are second messengers that are essential in vision, muscle contraction, neurotransmission, exocytosis, cell growth and differentiation. These molecules are degraded by a family of enzymes known as phosphodiesterases (PDES), which serve a critical function by regulating the intracellular concentration of cyclic nucleotides. Cyclic nucleotides are intracellular second messengers that play a key role in many physiological processes. The levels of these nucleotides are tightly regulated at the point of synthesis by receptor-linked enzymes (such as adenylyl or guanylyl cyclase) and at the point of degradation by a family of enzymes known as PDES. Our research involves the synthesis and docking of 7-substituted-8-aryl-2-morpholino-1,3-benzoxazine with known PDE3A, IC50 values. QSAR will then be used to predict the most active PDE3A inhibitor.