Haplotyping as a method to improve precision medicine
Haplotyping refers to the process of separating the genomic information into the specific information inherited from your mother and father. This process is sometimes called phasing and refers to the physical linkage of chromosomal polymorphisms. Phasing is important as genetic information present on one chromosome may modulate protein expression by overriding the information on the other parental chromosome and affect the patient’s response to drugs or influence how immune function is affected in bone-marrow transplantation. Projects in this area are focussed on how haplotypes affect immune responses and use modern tissue and molecular processing techniques combined with next generation sequencing and data analysis processes.