The Neurobiology theme investigates the biology and diseases associated with the nervous and musculoskeletal systems. Members have research interests ranging from anatomical and physiological studies, to biophysical studies of proteins, cellular and molecular analyses, and the use of in vivo models to study the pathophysiology of neuronal biology.
Researchers focus on the interaction of exercise in health and disease, and the general biology of disorders of the nervous system including Alzheimer’s, Parkinson’s and prion diseases, and Multiple Sclerosis.
Members have technical expertise in analytical ultracentrifugation, molecular interaction analysis, histology, the use of yeast and Drosophila models, next generation sequencing and bioinformatics, cell biology, molecular biology and single cell biochemistry.
Current projects include the study of protein-protein interactions in Alzheimer’s disease; the development of new diagnostics for neurodegenerative diseases; investigating the pathogenesis of Multiple Sclerosis; understanding how cells deal with misfolded proteins; and changes that occur in the musculature with exercise, in diseases such as osteoarthritis and with ageing.