New compounds to combat malaria
New antimalarial drugs are needed to combat growing resistance to existing treatments. LIMS researchers are part of a team that has developed a novel compound that causes the malaria parasite to burst and die. Their findings, published in Scientific Reports, could lead to new anti-malarial treatments.
Understanding insulin to improve diabetes treatment
Venomous sea-faring conesnails use insulin as a weapon to hunt prey. Professor Brian Smith and PhD student Nicholas Smith are part of an international collaboration that have used computational modelling to extend our understanding of conesnail insulin. Their findings, published in eLife, may lead to the development of new treatments for diabetes.
Efficient and reliable drug development
Click chemistry is an efficient and reliable approach for producing functional molecules. Dr Chris Smedley, Professor John Moses and collaborators have developed a new procedure to modify existing drugs based upon sulfur-fluoride exchange Click chemistry. Their findings, published as a ‘hot paper’ in Angewandte Chemie International Edition, will find wide application in drug discovery.
Designing next-generation materials
Understanding how proteins stick to surfaces is crucial in developing materials for industrial and medical purposes. Professor David Winkler and collaborators have used machine learning to improve our ability to accurately predict how proteins stick. Their findings, published in Scientific Reports, will aid the design of next-generation materials.