Nuclear Magnetic Resonance (NMR) Spectroscopy Facility

Capability B of the La Trobe Comprehensive Proteomics Platform (LTU-CPP)

The NMR facility provides an analysis service to the Melbourne area and regional Victoria and welcome expressions of interest from external users for projects either on a collaborative or fee-for-service basis. The facility is equipped with two NMR spectrometers operating at 1H frequencies 400 and 500 MHz respectively and access to higher field spectrometers is possible.

Capabilities include:

  • Non-destructive analysis of solids and liquids
  • Ability to run spectra on nuclei such as 1H, 13C, 15N, 19F and 31P
  • Data acquisition over temperature range to -150 - +150°C
  • Characterisation and structural analysis of biomolecules in water
  • Diffusion constant measurement
  • High throughput sample analysis


500 MHz (11.7 Tesla) NMR Spectrometer

Our narrow bore Bruker Avance III UltraShield Plus 500 MHz spectrometer has the capacity to acquire data on either solution or solids samples. Equipped with an inverse RT 5mm broadband gradient probe this instrument is suitable for structural analysis of biomolecules in water. The probe is tunable for 19F and other heteronuclei in the range 31P to 109Ag. With a magic angle spinning (MAS) solid state probe we are able to acquire data on solids samples with MAS for nuclei in the range 31P-15N and have the capability to observe 19F. The spectrometer is equipped with a variable temperature control unit capable setting the temperature in the range -150 -+150°C and automated data acquisition is possible on solution samples with a 16 position sample changer.

400 MHz (9.4 Tesla) NMR Spectrometer

Our narrow bore Bruker Avance III HD UltraShield Ascend 400 MHz spectrometer is equipped with a 5 mm broadband gradient probe tunable for nuclei in the resonance range 31P to 109Ag. In addition to 1H this spectrometer is tunable to 19F. The spectrometer is fitted with a sample changer capable of processing up to 60 samples in automation. NMR data can be acquired in the temperature range -150 – +150°C.


For more information about accessing the LIMS NMR Facility, please contact:
Dr Kristoffer Basse
T: +61 3 9479 2582