Modelling peptide foldamer interactions

Incorporation of non-natural amino acids, including b-amino acids and staples, into peptides can be used to engineer structural and proteolytic stability into the molecule. Bim BH3 peptides incorporating a hydrocarbon cross-link and cyclic b-amino acids is able to mimic the native a-helical structure of the Bim peptide, is ~100-fold more resistant to proteolysis, and is able to enter cells to block protein-protein interactions associated with apoptotic signaling.