Sharma – Synthetic organic chemistry: Heterocycles and natural product synthesis

Research

Group leader

Dr Pallavi Sharma

Senior Lecturer, College of Science, Health and Engineering

View profile, publications and contact details

Research overview

The development of new methods to synthesise functional molecules remains central to organic synthesis. Our group’s research focus is towards developing new synthetic methodology that delivers structurally diverse and complex chemical entities via rapid fusion of short lived reactive species. Our particular emphasis is towards up-valuing and reintroducing under-represented reagents by exploring their latent reactivity for heterocycles, spirocycles and natural products & analogue synthesis.

Working with our collaborators, we further seek to find novel application of these molecules in the field of biological, medicinal and material sciences.

Members

Group Leader

Dr Pallavi Sharma

Honours student

Adjoa Ampem-Lassen

Publications

Sharma P, Bhat SV, Ranga Prabhath, Molino A, Nauha E, Wilson DJ and Moses JE (2018) Synthesis of 1, 2, 4-Triazol-3-imines via Selective Stepwise Cycloaddition of Nitrile Imines with Organo-cyanamides, Org Lett., 20: 4263-4266.

Powell KJ, Richens JL, Bramble JP, Han L-C, Sharma P, O’Shea P and Moses JE (2018) Photochemical activity of membrane-localised polyketide derived marine natural products, Tetrahedron, 74: 1191-1198.

Smedley CJ, Barrow AS, Spiteri C, Giel MC, Sharma P and Moses JE (2017) Sulfur–Fluoride Exchange (SuFEx)‐Mediated Synthesis of Sterically Hindered and Electron‐Deficient Secondary and Tertiary Amides via Acyl Fluoride Intermediates, Chemistry-A European Journal, 23: 9990-9995.

Ranga Prabhath MR, Williams L, Bhat SV and Sharma P (2017) Recent advances in cyanamide chemistry: synthesis and applications, Molecules, 22: 615.

Bhat SV, Robinson D, Moses JE and Sharma P (2016) Synthesis of oxadiazol-5-imines via the cyclizative capture of in situ generated cyanamide ions and nitrile oxides, Org. Lett., 18: 1100-1103.

Han L-C, Stanley PA, Wood PJ, Sharma P, Kuruppu AI, Bradshaw TD and Moses JE (2016) Horner–Wadsworth–Emmons approach to piperlongumine analogues with potent anti-cancer activity, Org. and Biomol. Chem., 14: 7585-7593

Stanley PA, Spiteri C, Moore JC, Barrow AS, Sharma P and Moses JE (2016) Biomimetic Approaches Towards The Synthesis of Complex Dimeric Natural Products, Current Pharmaceutical Design, 22: 1628 – 1657.

Roe S, Gunaratnam M, Spiteri C, Sharma P, Alharthy RD, Neidle S and Moses JE (2015) Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors, Org. and Biomol. Chem.,13: 8500-8504.

Cousins ARO, Ritson D, Sharma P, Stevens MFG, Moses JE and Searle MS (2014) Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences, Chem. Commun., 50: 15202-15205.

Moore JC, Davies S, Walsh DA, Sharma P and Moses JE (2014) Formal synthesis of kingianin A based upon a novel electrochemically-induced radical cation Diels–Alder reaction, Chem. Commun., 50: 12523-12525.

Kimberley JP, Hen L-C, Sharma P and Moses JE (2014) Chemoselective Cyanation of Alkenyl Halides, Org. Lett., 16: 2158-2161.

Borreguero A, Sharma P, Moses JE and Rodríguez JF (2013) A novel 'click-chemistry' approach to flame retardant polyurethanes, React. Funct, Polym., 73: 1207-1212.

Research areas