Structure and function dynamics in cells through high-throughput quantitative imaging

Many of these imaging techniques are inherently non-quantitative; the intensities of the acquired images are mere qualitative representations of the targeted structures. There is a missing link between the actual cellular physiological parameters, such as contractility, hyperplasia, motility, etc., and what we are actually "seeing" in standard images.

Realizing this substantial gap, we have developed quantitative phase and polarization sensitive imaging could transform live cell imaging of cell contraction and movement by providing label-free, high-throughput functional imaging, which in turn will enable high throughput screening of new drug targets and molecules.