Radiopharmaceutical imaging agents

This is a collaborative project with the Australian Nuclear Science and Technology Organization (ANSTO) involving the development of ligand systems for applications in radiopharmaceutical imaging agent development. A number of ligand systems are being used in combination with metallic radionuclides such as Tc-99m, Cu-64 and Zr-89. Technetium-99m is the most widely used radionuclide in medical imaging and a wide array of Tc-99m labelled compounds are routinely used in diagnostic imaging. All isotopes of Tc are radioactive and new chemistry is often developed using Re and we have prepared a number of Re(I) complexes of NHC ligands and we recently reported the first example of a NHC ligand being labelled with Tc-99/99m.