Structure-activity relationships of novel antibacterial inhibitors of DHDPS

Dihydrodipicolinate synthase (DHDPS) catalyses the first step of the biosynthetic pathway which produces meso-DAP. It is essential for bacterial survival and so represents a new target for antibacterial drugs. A number of low MW molecules have been identified from a compound library using high throughput screening and we wish to further explore the structure-activity relationships of these hits through the synthesis of analogues.