Exploring the inhibition of PKA as a new therapeutic target for malaria

Malaria causes much damage to the health of the developing world. Protein kinase A (PKA) is important in the life cycle of the malaria parasite and may be an attractive target for inhibition. We are synthesising analogues of the isoquinoline compound A4 to test against this kinase and obtain SAR information, in order to develop a potent inhibitor to learn more about the role of PKA and its usefulness as a potential drug for malaria.