Molecular movies at pico and femtosecond timescales
The recent development of pump-probe and femtosecond time-delay experiments offer the possibility of studying biomolecular processes at high spatial and temporal scales so that "molecular movies" can be made at spatial resolutions approaching the atomic scale (Aquila et al., 2012). Our group will combine these new methodologies with advanced molecular modelling and data inversion techniques to gain unprecedented insights into protein dynamics, protein-protein interactions, structural and dynamic regulation of protein function. Combined with established stroboscopic techniques and emerging high-speed detector technology at the Australian Synchotron, this will allow studies of dynamics from millisecond to picosecond timescales.
This research ultimately aims to create 'molecular movies' of biomolecular interactions that will provide fundamental insights into protein function.