Mitochondrial protein processing and degradation by proteases

This research examines the contribution of the mitochondrial protein quality control machinery, particularly proteases to the biogenesis and clearance of normal and mutant mitochondrial proteins. It is anticipated that a thorough understanding of the kinetic partitioning of proteins (both normal and mutant) between their normal functional partners, chaperones and proteases will help in the successful development of small molecules for therapeutic intervention of some mitochondrial diseases.