Soares da Costa - Antibiotic and herbicide discovery
Dr Tatiana Soares da Costa
Research Fellow, College of Science, Health and Engineering
Resistance to current antibiotics and herbicides represents a major threat to global health and food security. Despite a continuous rise in resistance worldwide, no antibiotics or herbicides with a new mode of action have been introduced to the market in over 30 years.
The overall focus of our laboratory is to define the structure, function and regulation of essential proteins in bacteria and plants to guide the development of new classes of antibiotics and herbicides. Specifically, we aim to target multiple proteins simultaneously in essential biosynthetic pathways. Combining such multivalent inhibitors as an antibiotic or herbicide ‘cocktail’ provides a novel strategy for reducing the downstream development of resistance and has the potential to improve efficacy through synergism.