Perugini - Rational inhibitor design targeting drug-resistant bacteria, noxious weeds, and common age-related diseases

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Matthew PeruginiDr Matthew Perugini

Associate Professor, College of Science, Health and Engineering

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Research overview

Resistance to common antibiotics and herbicides is on the rise. There is thus an urgent need to discover new anti-microbial and anti-herbal agents, and an equally urgent need to characterise new drug targets. The Perugini laboratory studies the structure, function, regulation and inhibition of essential oligomeric enzymes, such as dihydrodipicolinate synthase (DHDPS), from the diaminopimelate biosynthesis pathway of bacteria & plants. Given their essentiality and multivalent nature, these oligomeric enzymes serve as excellent targets for the development of new anti-infection therapeutics and agrichemicals.

The Perugini lab is also interested in characterising the role of apolipoprotein E (apoE) in cardiovascular and Alzheimer’s disease. With these diseases accounting for approximately 30% of all deaths in Australia, effective intervention strategies for the treatment or prevention of cardiovascular and Alzheimer’s disease are urgently required. Studying the structure, function, and interactions of human apoE will provide insights into the development of such therapies.

Research areas