SFPQ, a universal nuclear hormone receptor modulator?
Recent studies have revealed that SFPQ interacts with a range of nuclear hormone receptors including peroxisome proliferator-activated receptor, retinoid X receptor, glucocorticoid receptor, thyroid hormone receptors, progesterone receptor, and androgen receptor. Some of these interactions have been implicated in cancer cell proliferation and apoptosis. These observations lead to the working hypothesis that SFPQ is a universal nuclear hormone receptor modulator.
This project aims to characterise the interactions between SFPQ and nuclear hormone receptors biophysically and structurally. The outcome of this project may offer a new platform to facilitate rational drug design for many metabolic diseases including diabetes by modulating the interactions between SFPQ and nuclear hormone receptors.