Novel plant defensins and their use in the treatment of proliferative diseases: WO 2013/056309 A1

Novel forms of plant defensins: WO 2013/056308

Treatment of proliferative diseases: AU 2011/269726

Treatment of proliferative diseases: WO 2011/160174  A1


For a complete list of publications see:
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Phan TK, Williams SA, Bindra GK, Lay FT, Poon IKH and Hulett MD (2019) Phosphoinositides: multipurpose cellular lipids with emerging roles in cell death, Cell Death Differentiation, doi: 10.1038/s41418-018-0269-2.

Lay FT, Ryan GF, Caria S, Phan TK, Veneer PK, White JA, Kvansakul M and Hulett MD (2019) Structural and functional characterization of the membrane-permeabilizing activity of Nicotiana occidentalis defensin NoD173 and protein engineering to enhance oncolysis, FASEB J, doi: 10.1096/fj.201802540R.

Paone S, Baxter AA, Hulett MD and Poon IKH (2018) Endothelial cell apoptosis and endothelial cell-derived extracellular vesicles in atherosclerosis, Cell. Mol. Life. Sci., doi: 10.1007/s00018-018-2983-9.

Järvå MF, Lay FT, Humble C, Phan KT, Poon IKH, Hulett* MD and Kvansakul* M (2018) The X-ray structure of of a carpet-like antimicrobial defensin–phospholipid membrane disruption complex, Nature Comm, 9: 1962. *co-corresponding authors

Järvå M, Phan TK, Lay FT, Caria S, Kvansakul M and Hulett MD (2018) Human b‐defensin 2 kills Candida albicans through phosphatidylinositol 4,5-bisphosphate–mediated membrane permeabilization, Science Advances, 4(7): eaat0979.

Tixeria R, Bo Shi, Parkes MAF, Hodge AL, Caruso S, Hulett MD, Baxter AA, Phan* TK and Poon* IKH (2018) Gasdermin E Does Not Limit Apoptotic Cell Disassembly by Promoting Early Onset of Secondary Necrosis in Jurkat T Cells and THP-1 Monocytes, Frontiers Immunology, doi: 10.3389/fimmu.2018.02842. *Co-corresponding authors

Phan TK, Lay FT and Hulett MD (2018) Importance of phosphoinositide binding by human β-defensin 3 for Akt-dependent cytokine induction, Immunol Cell Biol., 96(1): 54-67.

Shafee TM, Lay FT, Phan TK, Anderson MA and Hulett MD (2017) Convergent evolution of defensin sequence, structure and function, Cell Mol Life Sci., 74(4): 663-82.

Priebatsch KM, Kvansakul M, Poon IK and Hulett MD (2017) Functional regulation of the plasma protein histidine-rich glycoprotein by Zn2+ in settings of tissue injury, Biomolecules, 7(1): pii: E22.

Baxter AA, Poon IKH and Hulett MD (2017) The lure of the lipids: how defensins exploit membrane phospholipids to induce cytolysis in target cells, Cell Death Dis., 8(3): e2712.

Tixeira R, Caruso S, Paone S, Baxter AA, Atkin-Smith GK, Hulett MD and Poon IKH (2017) Defining the morphologic features and products of cell disassembly during apoptosis, Apoptosis, 22(3): 475-77.

Jiang L, Paone S, Caruso S, Atkin-Smith GK, Phan TK, Hulett MD and Poon IKH (2017) Determining the contents and cell origins of apoptotic bodies by flow cytometry, Sci Rep., 7(1): 14444.

Anasir MI, Baxter AA, Poon IKH, Hulett MD and Kvansakul M (2017) Structural and Functional Insight into Canarypox Virus CNP058 Mediated Regulation of Apoptosis, Viruses, 9(10): pii: E305.

Baxter AA, Poon IKH, Kvansakul M and Hulett MD (2017) Tumor cell membrane-targeting cationic antimicrobial peptides: novel insights into mechanisms of action and therapeutic prospects, Cellular and Molecular Life Sciences, 74(20): 3809-3825, front cover.

Jarva M, Lay FT, Hulett* MD and Kvansakul* M (2017) Structure of the defensin NsD7 in complex with PIP2 reveals that defensin : lipid oligomer topologies are dependent on lipid type, FEBS Lett., 591(16): 2482-2490. *co-corresponding authors

Atkin-Smith GK, Paone S, Zanker DJ, Duan M, Phan TK, Chen W, Hulett MD and Poon IK (2017) Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting, Sci Rep., 7: 39846.

Priebatsch KM, Poon IK, Patel KK, Kvansakul M and Hulett MD (2017) Divalent metal binding by histidine-rich glycoprotein differentially regulates higher order oligomerisation and proteolytic processing, FEBS Lett., 591(1): 164-76.

Putz EM, Mayfosh AJ, Kos K, Barkauskas DS, Nakamura K, Town L, Goodall KJ, Yee DY, Poon IKH, Baschuk N, Souza-Fonseca-Guimaraes F, Hulett* MD, Smyth* MJ (2017) NK cell heparanase controls tumor invasion and immune surveillance, J. Clin Invest., 127(7): 2777-2788. *co-corresponding authors

Baxter AA, Poon IKH and Hulett MD (2017) The plant defensin NaD1 induces tumor cell death via a non-apoptotic, membranolytic process, Cell Death Dis., 3: 16102.

Kvansakul M, Lay FT, Adda CG, Veneer PK, Baxter AA, Phan TK, Poon IK and Hulett MD (2016) Binding of phosphatidic acid by NsD7 mediates the formation of helical defensin-lipid oligomeric assemblies and membrane permeabilization, Proc Natl Acad Sci USA, 113(40): 11202-07.

Bleackley MR, Payne JA, Hayes BM, Durek T, Craik DJ, Shafee TM, Poon IK, Hulett MD, van der Weerden NL and Anderson MA (2016) Nicotiana alata defensin chimeras reveal differences in the mechanism of fungal and tumor cell killing and an enhanced antifungal variant, Antimicrob Agents Chemother., 60(10): 6302-12.

Shafee TM, Lay FT, Hulett MD and Anderson MA (2016) The defensins consist of two independent, convergent protein superfamilies, Mol Biol Evol., 33(9): 2345-56.

Jiang L, Tixeira R, Caruso S, Atkin-Smith GK, Baxter AA, Paone S, Hulett MD and Poon IKH (2016) Monitoring the progression of cell death and the disassembly of dying cells by flow cytometry, Nat Protoc., 11(4): 655-63.

Payne JA, Bleackley MR, Lee T-H, Shafee TM, Poon IKH, Hulett MD, Aguilar M-I, van der Weerden NL and Anderson MA (2016) The plant defensin NaD1 introduces membrane disorder through a specific interaction with the lipid, phosphatidylinositol 4,5 bisphosphate, Biochim Biophys Acta, 1858(6): 1099-109.

Corbo R, Ryan G, Haghighatbin M, Hogan C, Wilson D, Hulett MD, Barnard P and Dutton J (2016) Access to the parent tetrakis(pyridine)gold(III) trication, facile formation of rare Au(III) terminal hydroxides, and preliminary studies of biological properties, Inorg Chem., 55(6): 2830-39.

Phan TK, Lay FT, Poon IIK, Hinds MG, Kvansakul M and Hulett MD (2015) Human beta-defensin 3 contains a conserved oncolytic motif that binds PI(4,5)P2 to mediate tumour cell killing, Oncotarget, 7(2): 2054-69.

Baxter AA, Hulett* MD and Poon* IKH (2015) The phospholipid code: a key component of dying cell recognition, tumor progression and host-microbe interaction, Cell Death Diff., 22(12): 1893-905. *co-corresponding authors

Kuek LE, Leffler M, Mackay GA and Hulett MD (2015) The MS4A family: counting past 1, 2 & 3, Immunol Cell Biol., 94(1): 11-23.

Atkin-Smith GK, Tixeira R, Paone S, Mathivanan S, Collins C, Liem M, Goodall KJ, Ravichandran KS, Hulett MD and Poon IKH (2015) A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure, Nature Comm., 6: 7439.

Baxter AA, Richter V, Lay FT, Poon IKH, Adda CG, Veneer PK, Phan TK, Bleackley MR, Anderson MA, Kvansakul M and Hulett MD (2015) The tomato defensin TPP3 binds phosphatidylinositol (4,5)-bisphosphate via a conserved dimeric cationic grip conformation to mediate cell lysis, Mol Cell Biol., 35(11): 1964-78.

Lee AY, Phan TK, Hulett MD and Körner H (2015) The relationship between CCR6 and its binding partners: does the CCR6-CCL20 axis have to be extended? Cytokine, 72(1): 97-101.

Poon IKA, Baxter AA, Lay FT, Mills GD, Adda CG, Payne JAE, Phan TK, Ryan GF, White JA, Veneer PK, van der Weerden NL, Anderson MA, Kvansakul M and Hulett MD (2014) Phosphoinositide-mediated oligomerization of a defensin induces cell lysis, eLife, 3: e01808.

Poon IKA, Goodall KJ, Phipps S, Chow JDY, Pagler EB, Andrews DM, Conlan CL, Ryan GF, White JA, Wong MKL, Horan C, Matthaei KI, Smyth MJ and Hulett MD (2014) Mice deficient in heparanase exhibit impaired dendritic cell migration and reduced airway inflammation, Eur J Immunol., 44(4): 1016-30.

Goodall KJ, Poon IK, Phipps S and Hulett MD (2014) Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4, PLoS One, 9(10): e109596.

Kalra H, Adda CG, Liem M, Ang C-S, Mechler A, Simpson RJ, Hulett MD and Mathivanan S (2013) Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma, Proteomics, 13(22): 3354-64.

Patel KK, Poon IKA, Talbo GH, Perugini MA, Taylor NL, Ralph TJ, Hoogenraad NJ and Hulett MD (2013) New method for purifying Histidine-rich glycoprotein from human plasma redefines its functional properties, IUBMB Life, 65(6): 550-63.