Innate defense molecules as anti-cancer agents
Defensins are innate immunity proteins involved in host protection against pathogens. We have identified a subfamily of defensins that show promise as anti-cancer agents (Järvå et al., 2018, Järvå et al., 2018, Kvansakul et al., 2016, Baxter et al., 2015, Poon et al., 2014).
We have extensive programs dedicated to:
(1) Defining the molecular basis of the anti-cancer activity of defensins using a range of biochemical and biophysical methods including live cell imaging, electron microscopy, X-ray crystallography and small-angle X-ray scattering (in collaboration with Dr Marc Kvansakul).
(2) In vivo testing and pharmacokinetic properties of defensins in mouse models of tumour growth and progression.