Molecular mechanisms of A-beta toxicity in Alzheimer’s disease ‐ a role for the prion protein?

Recently it has been demonstrated that PrP can act as a receptor for Aβ oligomers which are implicated in the pathogenesis of Alzheimer's disease. Aβ is derived from a larger protein called the amyloid precursor protein (APP). We have well established cell lines expressing different forms of PrP and APP (which generate Aβ). These will be used to investigate the interactions of different forms of Aβ with PrP using a combination of biochemical and cell biological assays to determine the molecular mechanisms underlying this interaction.