Staff profile

Qualifications

• MSc, PhD, Melbourne

Teaching areas

• Excitable Tissues
• Neuromuscular Disorders

Supervision

• PhD students: Noni Larkins, Janelle Mollica

Professional involvement

• Chair of NH&MRC Research Fellowship Scheme Peer Review Panel B (2006-07)
• Member of NH&MRC Research Fellowship Committee (2006-07)

Membership of Editorial Boards

• Journal of Physiology (from 2002 onwards)
• Journal of Muscle Research & Cell Motility (from 2003 onwards)
• American Journal of Physiology Cell Physiology (from 2006 onwards)

Learned Societies

• Elected Councillor of Australian Physiological Society (2004 - )
• Special Interest Groups Coordinator for Australian Physiological Society (2005 - )
• Member of Australian Physiological Society
• Member of Physiological Society (UK)
• Member of American Physiological Society

Research interests

• Muscle physiology and exercise
• My research group studies the control of calcium release and contraction in normal and diseased muscle, making matched physiological and biochemical measurements on single muscle fibres
• Cardiac muscle function and disease

Recent publications

• Dutka TL & Lamb GD (2004). Effect of carnosine on excitation-contraction coupling in mechanically-skinned fibres of rat skeletal muscle. Journal of Muscle Research & Cell Motility 25, 203-13.
• Nielsen OB, Ortenblad N, Lamb GD & Stephenson DG (2004). Excitability of the T-tubular system in rat skeletal muscle: roles of K+ and Na+ gradients and Na+-K+ pump activity. Journal of Physiology 557, 133-46.
• Murphy RM, Stephenson DG & Lamb GD (2004). Effect of creatine on contractile force and sensitivity in mechanically skinned single fibers from rat skeletal muscle. American Journal of Physiology Cell Physiology 287, C1589-95.
• Pedersen TH, Nielsen OB, Lamb GD & Stephenson DG (2004). Intracellular acidosis enhances the excitability of working muscle. Science 305, 1144-1147.
• Dutka TL & Lamb GD (2004). Effect of low cytoplasmic [ATP] on excitation-contraction coupling in fast-twitch muscle fibres of the rat. Journal of Physiology 560, 451-68.
• Laver DR, O'Neill ER & Lamb GD (2004). Luminal Ca^2+-regulated Mg²⁺inhibition of skeletal RyRs reconstituted as isolated channels or coupled clusters. Journal of General Physiology 124, 741-58.
• Dulhunty AF, Cengia L, Young J, Pace SM, Harvey PJ, Lamb GD, Chan YN, Wimmer N, Toth I & Casarotto MG (2005). Functional implications of modifying RyR-activating peptides for membrane permeability. British Journal of Pharmacology 144, 743-54.
• Lamb GD (2005). Rippling muscle disease may be caused by "silent action" potentials in the tubular system of skeletal muscle fibers. Muscle & Nerve 31, 652-8.
• Verburg E, Murphy RM, Stephenson DG & Lamb GD (2005). Disruption of excitation-contraction coupling and titin by endogenous Ca^2+-activated proteases in toad muscle fibres. Journal of Physiology 564, 775-90.
• Dutka TL, Cole L & Lamb GD (2005). Calcium phosphate precipitation in the sarcoplasmic reticulum reduces action potential-mediated Ca²⁺release in mammalian skeletal muscle. American Journal of Physiology Cell Physiology 289, C1502-12.
• Murphy RM, Snow RJ & Lamb GD (2006). mu-Calpain and calpain-3 are not autolyzed with exhaustive exercise in humans. American Journal of Physiology Cell Physiology 290, C116-22.
• Verburg E, Dutka TL & Lamb GD (2006).  Long-lasting muscle fatigue: partial disruption of excitation-contraction coupling by the elevated cytosolic [Ca²⁺] during contractions. American Journal of Physiology Cell Physiology 290, C1199-1208.
• Yang Z, Ikemoto N, Lamb GD & Steele DS (2006). The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca²⁺release in permeabilized cardiomyocytes. Cardiovascular Research 70, 475-485.
• Trinh HH & Lamb GD (2006). Matching of sarcoplasmic reticulum and contractile properties in rat fast- and slow-twitch muscle fibres. Clinical and Experimental Pharmacology and Physiology 33, 591-600.
• Murphy RM, Verburg E & Lamb GD (2006). Ca²⁺activation of diffusible and bound pools of mu-calpain in rat skeletal muscle. Journal of Physiology 576, 595-612.
• Dutka TL & Lamb GD (2007a). Transverse tubular system depolarization reduces tetanic force in rat skeletal muscle fibers by impairing action potential repriming.  American Journal of Physiology Cell Physiology 292(6):C2112-21.
• Dutka TL & Lamb GD (2007b). Na+-K+ pumps in the transverse tubular system of skeletal muscle fibers preferentially use ATP from glycolysis. American Journal of Physiology Cell Physiology 293(3):C967-77.
• Murphy RM, Goodman CA, McKenna MJ, Bennie J, Leikis M & Lamb GD (2007). Calpain-3 is autolyzed and hence activated in human skeletal muscle 24 h following a single bout of eccentric exercise. Journal of Applied Physiology 103(3):926-31.
• Laver DR, Honen BN, Lamb GD & Ikemoto N. (2008). A domain peptide of the cardiac ryanodine receptor regulates channel sensitivity to luminal Ca⁽²⁺⁾ via cytoplasmic Ca⁽²⁺⁾ sites. European Biophysical Journal 37, 455-67
• Dutka TL, Murphy RM, Stephenson DG & Lamb GD. (2008). Chloride conductance in the transverse tubular system of rat skeletal muscle fibres: importance in excitation-contraction coupling and fatigue. Journal of Physiology 586: 875–887.
• Allen DG, Lamb GD & Westerblad H. (2008a). Skeletal muscle fatigue; cellular mechanisms. Physiological Reviews 88, 287-332.
• Allen DG, Lamb GD & Westerblad H. (2008b). Impaired calcium release during fatigue. Journal of Applied Physiology 104, 296-305.
• Murphy RM, Dutka TL & Lamb GD. (2008). Hydroxyl radical and glutathione interactions alter calcium sensitivity and maximum force of the contractile apparatus in rat skeletal muscle fibres. Journal of Physiology 586, 2203-2216.
• Murphy RM, Larkins NT, Mollica JP, Beard NA, Lamb GD (2009). Calsequestrin content and SERCA determine normal and maximal Ca²⁺ storage levels in sarcoplasmic reticulum of fast- and slow-twitch fibres of rat. Journal of Physiology (In press).