PHARMACOLOGY B

PHA2PGB

2018

Credit points: 15

Subject outline

This subject will introduce how variation in human molecular genetics may affect pharmacokinetics and pharmacodynamics of drugs. Examples will focus on mutations associated with metabolizing and excreting drugs and potential for toxicity. Immune responses from a cellular and molecular perspective will be introduced incorporating innate immunity, inflammation, chemical cascades, adaptive immunity and cells of the immune system. The capacity for clonal variations in acquired immunity based pharmacogenetics will be explored.

SchoolSchool of Molecular Sciences/LIMS

Credit points15

Subject Co-ordinatorHelen Irving

Available to Study Abroad StudentsYes

Subject year levelYear Level 2 - UG

Exchange StudentsYes

Subject particulars

Subject rules

Prerequisites BIO1CO or BIO1OF

Co-requisitesN/A

Incompatible subjectsN/A

Equivalent subjectsN/A

Special conditionsN/A

Readings

Resource TypeTitleResource RequirementAuthor and YearPublisher
ReadingsHuman GeneticsRecommendedLewis, R 20089TH ED MCGRAW-HILL. NEW YORK.
ReadingsImmunology-A Short CoursePreliminaryCoico, R and Sunshine, G 20086TH ED, WILEY-BLACKWELL

Graduate capabilities & intended learning outcomes

01. Use an understanding of the variability within and between populations to interpret effects on drug metabolism.

Activities:
The impact of variability within and between populations will be examined in lectures and reinforced in tutorials. Understanding will be assessed in the mid- semester test and final examination.
Related graduate capabilities and elements:
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)
Inquiry and Analytical Skills (Critical Thinking,Creative Problem-solving,Inquiry/Research)
Discipline -Specific Knowledge and Skills (Discipline-Specific Knowledge and Skills)

02. Evaluate how the variability in pharmocogentetics can cause toxic levels of drugs to circulate.

Activities:
The influence of variability in pharmacogentics on toxicity levels be explained in lectures and reinforced in tutorials. Understanding will be assessed in the final examination.
Related graduate capabilities and elements:
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)
Inquiry and Analytical Skills (Critical Thinking,Creative Problem-solving,Inquiry/Research)
Inquiry and Analytical Skills (Critical Thinking,Creative Problem-solving,Inquiry/Research)
Discipline -Specific Knowledge and Skills (Discipline-Specific Knowledge and Skills)

03. Assess different causes of pharmaceutical toxicity, including physiological change during human development, as a result of drug overdose or in a range of diseases.

Activities:
Causes of toxicity will be explained in lectures and reinforced in tutorials. Understanding will be assessed in the mid-semester test and final examination.
Related graduate capabilities and elements:
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)
Inquiry and Analytical Skills (Critical Thinking,Creative Problem-solving,Inquiry/Research)
Discipline -Specific Knowledge and Skills (Discipline-Specific Knowledge and Skills)

04. Explain the process of inflammation and the steps involved in initiation of the immune response to analyse drug interactions with the immune system.

Activities:
The inflamation and the immune recognition system will be presented in lectures. Understanding will be assessed in the final examnation.
Related graduate capabilities and elements:
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)
Inquiry and Analytical Skills (Critical Thinking,Creative Problem-solving,Inquiry/Research)
Inquiry and Analytical Skills (Critical Thinking,Creative Problem-solving,Inquiry/Research)
Personal and Professional Skills (Teamwork including leadership and working in groups,Ethical behaviour)
Discipline -Specific Knowledge and Skills (Discipline-Specific Knowledge and Skills)

05. Discuss how immunogenetics gives rise to clonal variation to fight infection.

Activities:
Immunogenetics will be presented during class time. Understanding will be assessed in the final examination.
Related graduate capabilities and elements:
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)
Literacies and Communication Skills (Writing,Speaking,Quantitative Literacy)
Discipline -Specific Knowledge and Skills (Discipline-Specific Knowledge and Skills)

Subject options

Select to view your study options…

Start date between: and    Key dates

Bendigo, 2018, Semester 2, Day

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Enrolment information

Subject Instance Co-ordinatorHelen Irving

Class requirements

Lecture Week: 31 - 43
Three 1.0 hours lecture per week on weekdays during the day from week 31 to week 43 and delivered via face-to-face.

Tutorial Week: 31 - 43
One 1.0 hours tutorial per week on weekdays during the day from week 31 to week 43 and delivered via face-to-face.

Assessments

Assessment elementComments% ILO*
2-hour written examination50 01, 02, 03, 04, 05
1-hour mid-semester test20 01, 02, 03, 04
One group review article (1500 words per student)30 01, 02, 03, 04

Singapore, 2018, Term L1, Day

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Enrolment information

Subject Instance Co-ordinatorJennifer Selkirk-Bell

Class requirements

Lecture Week: 02 - 07
One 36.0 hours lecture per study period on weekdays during the day from week 02 to week 07 and delivered via face-to-face.
"36-hours of Blended Lectures and Online Learning Activities in the teaching period delivered as a combination of face-to-face and online."

Tutorial Week: 02 - 07
One 12.0 hours tutorial per study period on weekdays during the day from week 02 to week 07 and delivered via face-to-face.
"12-hours of Tutorial or Directed Learning Activities during the teaching period and delivered via face-to-face or online."

Assessments

Assessment elementComments% ILO*
2-hour written examination50 01, 02, 03, 04, 05
1-hour mid-semester test20 01, 02, 03, 04
One group review article (1500 words per student)30 01, 02, 03, 04

Singapore, 2018, Term L3, Day

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Enrolment information

Subject Instance Co-ordinatorJennifer Selkirk-Bell

Class requirements

Lecture Week: 19 - 23
One 36.0 hours lecture per study period on weekdays during the day from week 19 to week 23 and delivered via face-to-face.
"36-hours of Blended Lectures and Online Learning Activities in the teaching period delivered as a combination of face-to-face and online."

Tutorial Week: 19 - 23
One 12.0 hours tutorial per study period on weekdays during the day from week 19 to week 23 and delivered via face-to-face.
"12-hours of Tutorial or Directed Learning Activities during the teaching period and delivered via face-to-face or online."

Assessments

Assessment elementComments% ILO*
2-hour written examination50 01, 02, 03, 04, 05
1-hour mid-semester test20 01, 02, 03, 04
One group review article (1500 words per student)30 01, 02, 03, 04

Singapore, 2018, Term L3, Night

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Enrolment information

Subject Instance Co-ordinatorJennifer Selkirk-Bell

Class requirements

Tutorial Week: 19 - 23
One 12.0 hours tutorial per study period on weekdays at night from week 19 to week 23 and delivered via face-to-face.
"12-hours of Tutorial or Directed Learning Activities during the teaching period and delivered via face-to-face or online."

Lecture Week: 19 - 23
One 36.0 hours lecture per study period on weekdays at night from week 19 to week 23 and delivered via face-to-face.
"36-hours of Blended Lectures and Online Learning Activities in the teaching period delivered as a combination of face-to-face and online."

Assessments

Assessment elementComments% ILO*
2-hour written examination50 01, 02, 03, 04, 05
1-hour mid-semester test20 01, 02, 03, 04
One group review article (1500 words per student)30 01, 02, 03, 04