MOLECULAR GENETICS

GEN3HMG

2018

Credit points: 30

Subject outline

This subject introduces students to more advanced concepts and methods in human and molecular genetics. The topics covered include: genes and development including molecular regulation of embryogenesis, stems cells and cancer; Model organisms, including Mice and fruit fly; Immunogenetics; cancer; the genetic structure of human populations; molecular evidence for human evolution; forensic genetics, genomics applications and ethical implications; functional mapping of single and multifactorial human genetic diseases, introduction to gene and cellular therapy.

SchoolSchool of Molecular Sciences/LIMS

Credit points30

Subject Co-ordinatorAdam Hart

Available to Study Abroad StudentsYes

Subject year levelYear Level 3 - UG

Exchange StudentsYes

Subject particulars

Subject rules

Prerequisites GEN2MHG or GEN2HMG

Co-requisitesN/A

Incompatible subjectsN/A

Equivalent subjectsN/A

Special conditionsN/A

Readings

Resource TypeTitleResource RequirementAuthor and YearPublisher
ReadingsGenetics Analysis and PrinciplesRecommendedBrooker, RMCGRAW HILL 2011
ReadingsHuman Embryology and developmentalRecommendedCarlson, BELSEVIER 2013
ReadingsHuman Evolutionary GeneticsRecommendedJobling M.A, Hurles. M and Tyler-Smith CGARLAND SCIENCE 2004
ReadingsHuman Molecular Genetics 4th EditionRecommendedStrachan, T and Read, A.P.GARLAND SCIENCE 2011
ReadingsPrinciple of DevelopmentRecommendedWolpert, L and Tickle COXFORD 2010
ReadingsJaneway's Immunobiology 7th editionRecommendedMurphy, Travers and WalportGarland Science
ReadingsConcepts of Genetics, 10th, international editionRecommendedKlug et. al.,Pearson

Graduate capabilities & intended learning outcomes

01. Analyse and evaluate experimental and published data relating to molecular genetics experiments to prepare a comprehensive laboratory report.

Activities:
Information about the research area, experimental and data analysis techniques, and report preparation guidelines are outlined in the practical manual and associated online (moodle) resources and are further explained in practical class/es and tutorial/s. Students have to conduct experiments in the practical classes, analyse and write up experimental results.
Related graduate capabilities and elements:
Literacies and Communication Skills
Literacies and Communication Skills
Inquiry and Analytical Skills
Inquiry and Analytical Skills
Inquiry and Analytical Skills
Personal and Professional Skills
Personal and Professional Skills
Discipline -Specific Knowledge and Skills

02. Articulate and apply advanced genetics concepts and analytical methods in the genetic control of development, the structure and function of genes and chromosomes, human variation, genetic disease and genome biology.

Activities:
Genetics concepts and analytical methods are explained in lectures and recommended reading. Students participate in theory revision sessions. Students can revise content and practice their knowledge via online resources (Moodle, Peerwise) including: practice exam questions, discussion groups, lectopia and other materials. Students attempt 2 in-class multiple choice exams and can use the feedback on these exams to structure their revision before the end-of-semester examination (2 x 1.5 hour theory exams).
Related graduate capabilities and elements:
Inquiry and Analytical Skills
Inquiry and Analytical Skills
Discipline -Specific Knowledge and Skills

03. Apply advanced molecular genetics laboratory methods to generate and analyse high quality experimental data.

Activities:
Students will learn and apply techniques for microscopy, micropippetting, electrophoresis, column chromatography, blood culture, karyotyping, histochemistry, polymerase chain reaction, restriction enzyme digestion, image analysis and statistical analysis in the practical classes.
Related graduate capabilities and elements:
Literacies and Communication Skills
Inquiry and Analytical Skills
Personal and Professional Skills
Discipline -Specific Knowledge and Skills

04. Analyse, discuss and present research information to peers and a scientific audience.

Activities:
Journal Club presentations: Information necessary for completing this assignment is available in the practical manual as well as online guidelines. Students need to select, read and discuss a research article from a provided list. Students present a discussion and critique of the research study, followed by answering questions from the academics. Written feedback is given by academics, demonstrators and peers. Clinical case studies poster presentation: Students have to diagnose a genetic disease from provided clinical data. Instructions to prepare a poster presentation will be given. Posters will be presented in a poster symposium, followed by questions from academics. Written feedback is given by academics, demonstrators and peers.
Related graduate capabilities and elements:
Discipline -Specific Knowledge and Skills
Personal and Professional Skills
Personal and Professional Skills
Personal and Professional Skills
Inquiry and Analytical Skills
Inquiry and Analytical Skills
Inquiry and Analytical Skills
Literacies and Communication Skills
Literacies and Communication Skills
Literacies and Communication Skills

05. Use bioinformatics to solve genetics problems.

Activities:
Information to complete assignments is available in the practical manual and online guidelines. Individually and in small groups, students will use the genetics computer lab to access online worksheets, tutorials, genome databases and bioinformatics tools to solve genetics problems: - Students have to complete bioinformatics worksheets using online tutorials and database mining tools. - Students generate VNTR and RFLP (DNA variation) data in the laboratory and then use online sequence analysis and comparison tools to discover ApoB and PTC genotype/phenotype corelation, then analyse and describe the evolution of these genotypes and traits. - Students use online databases and apply gene search and analysis tools to analyse clinical case study data.
Related graduate capabilities and elements:
Literacies and Communication Skills
Inquiry and Analytical Skills
Inquiry and Analytical Skills
Inquiry and Analytical Skills
Personal and Professional Skills
Personal and Professional Skills
Discipline -Specific Knowledge and Skills

06. Apply clinical problem solving skills to diagnose genetic diseases.

Activities:
Information about the assignment is available from the practical manual and a practical briefing is given on clinical problem solving. Students analyse clinical genetics data by DNA bioinformatics or karyotype analysis using online guides and resources, and diagnose the genetic disease. Students discuss their findings with demonstrators in a tutorial. Students then prepare a case study poster and present the poster (5 minutes), which is followed by questions (10 minutes) from genetics academics in a poster symposium. Written feedback on the posters and poster presentations is given by academics, demonstrators and peers. Prizes are awarded to the top group in each practical class.
Related graduate capabilities and elements:
Discipline -Specific Knowledge and Skills
Personal and Professional Skills
Personal and Professional Skills
Personal and Professional Skills
Inquiry and Analytical Skills
Inquiry and Analytical Skills
Inquiry and Analytical Skills
Literacies and Communication Skills
Literacies and Communication Skills
Literacies and Communication Skills

07. Discuss and debate the ethical implications of Genetics research.

Activities:
In the first session, groups of 8 students will be provided with published opinion and research on current genetics topics such as: criminal DNA databases; control of DNA information; saviour siblings; paternity; predictive genetic testing; forensic medicine and Informed consent. Students will discuss the topic and undertake further independent research. In a second session students will form groups of four to take opposing sides in the discussion mediated by a tutor. Opposing groups will summarize their arguments in front of academics and class in the final session.
Related graduate capabilities and elements:
Literacies and Communication Skills

Subject options

Select to view your study options…

Start date between: and    Key dates

Melbourne, 2018, Semester 1, Day

Overview

Online enrolmentYes

Maximum enrolment size100

Enrolment information Quota due to limited lab space. Merit based quota on academic performance in GEN2MHG.

Subject Instance Co-ordinatorAdam Hart

Class requirements

Lecture Week: 10 - 22
Four 1.0 hours lecture per week on weekdays during the day from week 10 to week 22 and delivered via face-to-face.
"Or Delivery Method: On-Line"

Laboratory Class Week: 10 - 22
One 6.0 hours laboratory class per week on weekdays during the day from week 10 to week 22 and delivered via face-to-face.

Assessments

Assessment elementComments% ILO*
Group presentations (25min total) (1500 words equivalent)Group presentations including journal club presentation (10min) and case study presentation and questions (15 min)16 02, 04, 05, 06
Laboratory & ethical assessment (2000 words equivalent)Includes 3 reports, 2 worksheets, clay embryo model and ethics debate24 01, 02, 03, 05, 07
Two 1.5-hour exams (end of semester)50 02
Two mid-semester tests (30 minutes each)10 02

Singapore, 2018, Week 45-07, Night

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Enrolment information

Subject Instance Co-ordinatorYeliz Boglev

Class requirements

Practical Week: 45
One 72.0 hours practical per study period on weekdays at night in week 45 and delivered via face-to-face.
"72 hours consisting of wet/dry/simulation activities."

Lecture Week: 45
One 48.0 hours lecture per study period on weekdays at night in week 45 and delivered via face-to-face.

Assessments

Assessment elementComments% ILO*
Group presentations (25min total) (1500 words equivalent)Group presentations including journal club presentation (10min) and case study presentation and questions (15 min)16 02, 04, 05, 06
Laboratory & ethical assessment (2000 words equivalent)Includes 3 reports, 2 worksheets, clay embryo model and ethics debate24 01, 02, 03, 05, 07
Two 1.5-hour exams (end of semester)50 02
Two mid-semester tests (30 minutes each)10 02

Singapore, 2018, Week 45-07, Day

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Enrolment information

Subject Instance Co-ordinatorYeliz Boglev

Class requirements

Practical Week: 45
One 72.0 hours practical per study period on weekdays during the day in week 45 and delivered via face-to-face.
"72 hours consisting of wet/ dry/simulation activities."

Lecture Week: 45
One 48.0 hours lecture per study period on weekdays during the day in week 45 and delivered via face-to-face.

Assessments

Assessment elementComments% ILO*
Group presentations (25min total) (1500 words equivalent)Group presentations including journal club presentation (10min) and case study presentation and questions (15 min)16 02, 04, 05, 06
Laboratory & ethical assessment (2000 words equivalent)Includes 3 reports, 2 worksheets, clay embryo model and ethics debate24 01, 02, 03, 05, 07
Two 1.5-hour exams (end of semester)50 02
Two mid-semester tests (30 minutes each)10 02