MEDICINAL AND ORGANIC CHEMISTRY

CHE2MOC

2018

Credit points: 15

Subject outline

CHE2MOCĀ is an elective second year chemistry subject, which is taken in conjunction with CHE2FCA. This subject introduces studentsĀ to medicinal chemistry, with an emphasis on how drugs interact with their molecular targets of lipids, carbohydrates, nucleic acids and proteins. The organic chemistry component is focused on the properties, nomenclature, reactions and mechanisms of key functional groups used in organic synthesis, including the effects observed on stereochemistry. Learning activities include lectures, tutorials, online learning activities, workshops and laboratory classes.

SchoolSchool of Molecular Sciences/LIMS

Credit points15

Subject Co-ordinatorBelinda Abbott

Available to Study Abroad StudentsYes

Subject year levelYear Level 2 - UG

Exchange StudentsYes

Subject particulars

Subject rules

Prerequisites Either CHE1CHF or CHE1GEN, and CHE1APL

Co-requisites CHE2FCA

Incompatible subjectsN/A

Equivalent subjectsN/A

Special conditionsN/A

Readings

Resource TypeTitleResource RequirementAuthor and YearPublisher
ReadingsIntroduction to Medicinal ChemistryPrescribedPatrick, G., 2013Oxford University Press
ReadingsOrganic ChemistryPrescribedMcMurry, J., 2016Thomson-Brooks/Cole

Graduate capabilities & intended learning outcomes

01. Explain the fundamental concepts of medicinal chemistry.

Activities:
During lectures students will answer short questions individually or as part of small groups, reinforcing the lecture material. Students will also work through problems that reinforce the concepts associated with this ILO individually. This material will be covered in tutorials and students will be required to orally explain their answers and participate in tutorial discussions. Written tasks and online quizzes will be will be used to reinforce and assess this ILO.

02. Illustrate understanding of the ways drugs interact with their molecular targets.

Activities:
During lectures students will answer short questions individually or as part of small groups, reinforcing lecture material. Written tasks and online quizzes will be used to reinforce and assess the concepts associated with this ILO.

03. Employ concepts of bonding to explain the properties of organic compounds.

Activities:
Students will work through problems that reinforce the concepts associated with this ILO individually. During lectures students will answer short questions individually or as part of small groups. This material will also be covered in workshops and students will be required to orally explain their answers and participate in discussions. Written worksheets and in class testing will be used to reinforce and assess this ILO.

04. Design synthetic schemes for the preparation of organic compounds showing understanding of reaction mechanisms.

Activities:
During lectures students will answer short questions individually or as part of small groups, reinforcing lecture material. The concepts associated with this ILO will be reinforced using online quizzes, administered using LMS. Written worksheets and in class testing will be used to reinforce and assess this ILO.

05. Demonstrate practical skills needed to conduct chemical synthesis, chemical analysis and be able to interpret and report the results of spectroscopic measurements.

Activities:
Working individually or in small groups students will aquire practical skills required for the manipulation of chemicals for chemical synthesis. Working individually or in small groups students will learn techniques (chemical and instrumental) used in modern chemical analysis. Working individually or in small groups students will learn how to make spectroscopic measurements. Students will develop skills in the preparation of laboratory reports, including the use of correct and appropriate prose and presentation of experimental data and results.

Subject options

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Start date between: and    Key dates

Melbourne, 2018, Semester 1, Day

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Enrolment information

Subject Instance Co-ordinatorBelinda Abbott

Class requirements

Laboratory Class Week: 10 - 22
One 3.0 hours laboratory class per week on weekdays during the day from week 10 to week 22 and delivered via face-to-face.
"Weekly 3hr class. Includes 6 wet lab sessions 6 additional learning activities (seminar and computer laboratory exercises) as required."

Lecture Week: 10 - 22
Two 1.0 hours lecture per week on weekdays during the day from week 10 to week 22 and delivered via face-to-face.

Tutorial Week: 10 - 22
One 1.0 hours tutorial per week on weekdays during the day from week 10 to week 22 and delivered via face-to-face.

Seminar Week: 10 - 10
One 3.0 hours seminar per week on weekdays during the day from week 10 to week 10 and delivered via face-to-face.
"Scheduled at the same time as the laboratory class"

Computer Laboratory Week: 11 - 13
One 3.0 hours computer laboratory per week on weekdays during the day from week 11 to week 13 and delivered via face-to-face.
"Scheduled at the same time as the laboratory class"

Assessments

Assessment elementComments% ILO*
LMS online quizzes (300 words equivalent)10 01, 02
Laboratory work and reports (1400 words equivalent)Hurdle: Students must complete minimum 75% of lab assessment as required by the Royal Australian Chemical Institute (RACI). Students must also obtain a score of at least 50% for the laboratory component of the subject.30 03, 04, 05
In-class test during semester (300 words equivalent)10 03, 04
Examinations (2 x 1.25 hour exams) or equivalent assessment tasks during semester (2500 words equiv)50 01, 02, 03, 04