MEDICINAL CHEMISTRY A

CHE2MCA

2018

Credit points: 15

Subject outline

Students will be introduced to the chemical principles that are required to understand the action and behaviours of a drug compound. The main areas of study include an introduction to the chemistry and nomenclature of carbohydrates, lipids, steroids and heterocyclic compounds and some of their reactions. This unit will provide an understanding of how the chemical structure and behaviour of drug molecules relate to the activity of drugs in biological systems, and how this knowledge can be used to devise strategies for drug design and principles of drug structure-activity relationships (SAR and QSAR), drug-receptor interactions and drugs metabolism. This unit will also contain a computer based practical component.

SchoolSchool of Molecular Sciences/LIMS

Credit points15

Subject Co-ordinatorJasim Al-Rawi

Available to Study Abroad StudentsYes

Subject year levelYear Level 2 - UG

Exchange StudentsYes

Subject particulars

Subject rules

Prerequisites CHE1C1A, CHE1C1B

Co-requisitesN/A

Incompatible subjectsN/A

Equivalent subjectsN/A

Special conditionsN/A

Readings

Resource TypeTitleResource RequirementAuthor and YearPublisher
ReadingsAn Introduction to Medicinal ChemistryPrescribedPatrick, G., 2013 (5th edition)Oxford University Press
ReadingsMedicinal Chemistry: An IntroductionRecommendedThomas, G., 2007 (2nd edition)Wiley
ReadingsLecture semi-notes and practical are lodged on the LMSPrescribedLa Trobe UniversityLa Trobe University
ReadingsOrganic chemistryPrescribedBruice, P. Y., 2017 (8th edition)Pearson

Graduate capabilities & intended learning outcomes

01. Demonstrate an understanding of the chemistry (structures, naming, some synthesis methods and reactivity) of important biological molecules such as carbohydrates, lipids, steroids and heterocyclic molecules.

Activities:
Taught in lectures, tutorials, practical workshops, practice problems from text. Assessed in tests and exam.

02. Demonstrate an advanced understanding of the chemistry of organic compounds by describing functional group chemistry and how this impacts on activity with cell-receptors (drug structure-activity relationships ,SAR), identifying pharmacophore, and by describing and drawing the major synthesis steps used to modify organic molecules to enhance drug efficacy.

Activities:
Taught in lectures, tutorials, practical workshops, practice problems from text and online. Assessed in tests, exam and practical workshop reports.

03. Demonstrate the use of the major concepts and language of pharmaceutical and medicinal chemistry.

Activities:
Taught in lectures, tutorials, practical workshops, practice problems from text and online. Assessed in tests, exams and practical workshop reports.

04. Recognise drug structures, identify and predict likely metabolic and elimination pathways, describe likely routes of administration by considering issues such as solubility and metabolism.

Activities:
Taught in lectures, tutorials, practical workshops, practice problems from text and online. Assessed in tests, exams and practical workshop reports

05. Apply knowledge to devise strategies for drug design and principles of drug structure-activity relationships (SAR and QSAR)

Activities:
Taught in lectures, tutorials, practical workshops, practice problems from text and online. Assessed in tests, exam and practical workshop reports.

Subject options

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Start date between: and    Key dates

Bendigo, 2018, Semester 1, Day

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Enrolment information

Subject Instance Co-ordinatorJasim Al-Rawi

Class requirements

Practical Week: 15 - 15
One 3.0 hours practical per study period on weekdays during the day from week 15 to week 15 and delivered via face-to-face.

Tutorial Week: 11 - 22
One 1.0 hours tutorial per week on weekdays during the day from week 11 to week 22 and delivered via face-to-face.

Lecture Week: 10 - 22
Three 1.0 hours lecture per week on weekdays during the day from week 10 to week 22 and delivered via face-to-face.

Computer Laboratory Week: 13 - 16
One 3.0 hours computer laboratory per study period on weekdays during the day from week 13 to week 16 and delivered via face-to-face.
"Computer Laboratory simulation"

Assessments

Assessment elementComments% ILO*
One 3-hour end-of-semester written examination60 01, 02, 03, 04, 05
Two in-class tests (15% each) (equivalent to 600-words total)30 01, 02, 03
Two laboratory reports (5% each) (equivalent to 300 words total)10 02, 03

Singapore, 2018, Term L3, Day

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Enrolment information

Subject Instance Co-ordinatorJennifer Selkirk-Bell

Class requirements

Tutorial Week: 19 - 23
One 12.0 hours tutorial per study period on weekdays during the day from week 19 to week 23 and delivered via face-to-face.
"12-hours of tutorials or online quizzes during the teaching period and delivered via face-to-face or online."

Lecture Week: 19 - 23
One 36.0 hours lecture per study period on weekdays during the day from week 19 to week 23 and delivered via face-to-face.
"36-hours of Blended Lectures and Online Learning Activities in the teaching period delivered as a combination of face-to-face and online."

Computer Laboratory Week: 19 - 23
One 3.0 hours computer laboratory per study period on weekdays during the day from week 19 to week 23 and delivered via face-to-face.

Practical Week: 19 - 23
One 3.0 hours practical per study period on weekdays during the day from week 19 to week 23 and delivered via face-to-face.

Assessments

Assessment elementComments% ILO*
One 3-hour end-of-semester written examination60 01, 02, 03, 04, 05
Two in-class tests (15% each) (equivalent to 600-words total)30 01, 02, 03
Two laboratory reports (5% each) (equivalent to 300 words total)10 02, 03

Singapore, 2018, Term L3, Night

Overview

Online enrolmentYes

Maximum enrolment sizeN/A

Enrolment information

Subject Instance Co-ordinatorJennifer Selkirk-Bell

Class requirements

Tutorial Week: 19 - 23
One 12.0 hours tutorial per study period on weekdays at night from week 19 to week 23 and delivered via face-to-face.
"12-hours of tutorials or online quizzes during the teaching period and delivered via face-to-face or online."

Lecture Week: 19 - 23
One 36.0 hours lecture per study period on weekdays at night from week 19 to week 23 and delivered via face-to-face.
"36-hours of Blended Lectures and Online Learning Activities in the teaching period delivered as a combination of face-to-face and online."

Computer Laboratory Week: 19 - 23
One 3.0 hours computer laboratory per study period on weekdays at night from week 19 to week 23 and delivered via face-to-face.

Practical Week: 19 - 23
One 3.0 hours practical per study period on weekdays at night from week 19 to week 23 and delivered via face-to-face.

Assessments

Assessment elementComments% ILO*
One 3-hour end-of-semester written examination60 01, 02, 03, 04, 05
Two in-class tests (15% each) (equivalent to 600-words total)30 01, 02, 03
Two laboratory reports (5% each) (equivalent to 300 words total)10 02, 03