ARC Future Fellow, Lab Head
Faculty of Science, Technology and Engineering
School of Molecular SciencesPhysical Science 4 room 423B/423 (L), Melbourne (Bundoora)
BSc Hons, PhD La Trobe.
Biochemistry and Molecular Biology
Suzi completed her Bachelor of Science in 1992 with 1st class Honours in Biochemistry at La Trobe University. She undertook a PhD working on the mechanism of action of anticancer drugs under the supervision of Professor Don Phillips at La Trobe University. After completion of her PhD, Suzi worked for 2 years in the Chromosome Research laboratory of Associate Professor Andy Choo at the Murdoch Childrens Research Institute. Here, she researched the properties of Human Artificial Chromosomes and transgenic mice defective in essential centromere proteins. Suzi then returned to La Trobe University and was awarded a La Trobe University Postdoctoral Research Fellowship in 2001. The following year, she was the recipient of a 5 year Discovery grant (in collaboration with Professor Don Phillips) and an Australian Research Fellowship from the Australian Research Council.
Cutts, S.M., Swift, L.P., Rephaeli, A., Nudelman, A., and Phillips, D.R. (2003) Sequence specificity of adriamycin-DNA adducts in human tumor cells, Mol Cancer Ther.2: 661-670.
Cutts, S.M., Rephaeli, A., Nudelman, A., Hmelnitsky, I. and Phillips, D.R. (2001) Molecular basis for the synergistic interaction of Adriamycin with the formaldehyde-releasing prodrug AN-9, Cancer Research 6: 8194-8202.
Saffery, R., Wong, L.H., Irvine, D.V., Bateman, M.A., Griffiths, B., Cutts, S.M., Cancilla, M.R., Cendron, A.C., Stafford, A.J., and Choo, K.H.A. (2001) Construction of neocentromere-based human minichromosomes by telomere-associated chromosomal truncation, Proceedings of the National Academy of Sciences USA, 98: 5705-5710.
Phillips, D.R., Cutts, S.M., Cullinane, C., and Crothers, D.M. (2001) In vitro transcription assay for determining DNA sequence specificity of drugs which interact with DNA. Methods in Enzymology, 340: 466-485.
Parker, B.S., Cutts, S.M. and Phillips, D.R. (2001) Cytosine methylation enhances mitoxantrone-DNA adduct formation at CpG dinucleotides, Journal of Biological Chemistry, 276: 15953-15960.
Cutts, S.M., Cullinane, C (equal first author)., Panousis, C., and Phillips, D.R. (2000) Interstrand crosslinking by Adriamycin in nuclear and mitochondrial DNA of MCF-7 cells. Nucleic Acids Research 28: 1019-1025.
Cutts, S.M., Fowler, K.J., Kile, B.T., Hii, L.L., O'Dowd, R.A., Hudson, D.F., Saffery, R., Kalitsis, P., Earle, E., and Choo, K.H. (1999) Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice. Human Molecular Genetics 8:1145-55.
Hudson, D.F., Fowler, K.J., Earle, E., Saffery, R., Kalitsis, P., Trowell, H., Hill, J., Wretford, N.G., de Kretser, D.M., Cancilla, M.R., Howman, E., Hii, L., Cutts, S.M., Irvine, D.V., and Choo, K.H.A., (1998) Centromere Protein B null mice are mitotically and meiotically normal but have lower body and testis weights. Journal of Cell Biology 141: 309-319.
Cutts, S.M., Parsons, P.G., Sturm, R.A., and Phillips, D.R. (1996) Adriamycin-induced DNA adducts inhibit the DNA interactions of transcription factors and RNA polymerase. Journal of Biological Chemistry 271: 5422-5429.
Cutts, S.M., and Phillips, D.R. (1995) Use of oligonucleotides to define the site of interstrand crosslinks induced by Adriamycin. Nucleic Acids Research 23: 2450-2456.